Molecular Hydrogen: an Emerging Therapeutic Medical Gas for Brain Disorders
Molecular Hydrogen: an Emerging Therapeutic Medical Gas for Brain Disorders
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DOI：
10.1007/s12035-022-03175-w
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发表时间：
2022-12-26
影响因子：
5.1
通讯作者：
Yang，Luodan
中科院分区：
文献类型：
--
作者：
Wu，Chongyun;Zou，Peibin;Yang，Luodan
氧化应激和神经炎症是参与各种神经退行性疾病或脑损伤的起始和进展的主要生理病理变化。自2007年氢能降低缺血性中风中过氧亚硝酸根阴离子和羟基自由基水平的里程碑式发现以来，分子氢的抗氧化和抗炎作用引起了广泛的关注。由于其优异的抗氧化和抗炎特性，通过不同给药途径的氢疗法对广泛的脑部疾病表现出巨大的治疗潜力，包括阿尔茨海默病、新生儿缺氧缺血性脑病、抑郁症、焦虑症、创伤性脑损伤、缺血性中风、帕金森病和多发性硬化症。本文综述了氢的给药途径、氢对上述脑疾病的影响以及氢神经保护的主要机制。最后，我们讨论了氢疗法在脑疾病中的剩余问题和挑战。我们的结论是，了解确切的分子靶点，寻找新的途径，并确定最佳剂量的氢管理是未来的研究和应用的关键。
Oxidative stress and neuroinflammation are the main physiopathological changes involved in the initiation and progression of various neurodegenerative disorders or brain injuries. Since the landmark finding reported in 2007 found that hydrogen reduced the levels of peroxynitrite anions and hydroxyl free radicals in ischemic stroke, molecular hydrogen’s antioxidative and anti-inflammatory effects have aroused widespread interest. Due to its excellent antioxidant and anti-inflammatory properties, hydrogen therapy via different routes of administration exhibits great therapeutic potential for a wide range of brain disorders, including Alzheimer’s disease, neonatal hypoxic-ischemic encephalopathy, depression, anxiety, traumatic brain injury, ischemic stroke, Parkinson’s disease, and multiple sclerosis. This paper reviews the routes for hydrogen administration, the effects of hydrogen on the previously mentioned brain disorders, and the primary mechanism underlying hydrogen’s neuroprotection. Finally, we discuss hydrogen therapy’s remaining issues and challenges in brain disorders. We conclude that understanding the exact molecular target, finding novel routes, and determining the optimal dosage for hydrogen administration is critical for future studies and applications.