FGF8-mediated signaling regulates tooth developmental pace during odontogenesis
FGF8-mediated signaling regulates tooth developmental pace during odontogenesis
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FGF8介导的信号在牙形成过程中调节牙齿发育速度
DOI：
10.1016/j.jgg.2021.08.009
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发表时间：
2022
影响因子：
5.9
通讯作者：
ing
中科院分区：
文献类型：
--
作者：
Lin Chensheng;Ruan Ningsheng;Li Linjun;Chen Yibin;Hu Xiaoxiao;Chen Yiping;Hu Xuefeng;Zhang Y;ing
人和小鼠牙齿发育过程高度保守，发育速度差异显著，是研究器官生长调控机制的理想模型系统。本研究通过操纵人和小鼠牙齿组织的异源重组，证明牙齿间充质细胞在牙齿发育过程中起主导作用，而成纤维细胞生长因子8可能在牙齿发育过程中起关键作用。小鼠牙间质中成纤维细胞生长因子8信号的强制激活促进细胞增殖，通过p38和PI3K-Akt细胞内信号通路阻止细胞凋亡，并促进牙胚细胞周期从G1期向S期的转变。我们的结果提供了令人信服的证据，表明外部信号可以深刻地影响牙齿的发育速度，而牙齿间充质FGF8可能是在哺乳动物牙齿发生过程中以非细胞自主的方式控制发育速度的关键因素。
The developing human and mouse teeth constitute an ideal model system to study the regulatory mechanism underlying organ growth control since their teeth share highly conserved and well-characterized developmental processes,and their developmental tempo varies notably.In the current study,we manipulated heterogenous recombination between human and mouse dental tissues and demonstrated that the dental mesenchyme dominates the tooth developmental tempo and FGF8 could be a critical player during this developmental process.Forced activation of FGF8 signaling in the dental mesenchyme of mice promoted cell proliferation,prevented cell apoptosis via p38 and perhaps PI3K-Akt intracellular signaling,and impelled the transition of the cell cycle from G1- to S-phase in the tooth germ,resulting in the slowdown of the tooth developmental pace.Our results provide compelling evidence that extrinsic signals can profoundly affect tooth developmental tempo,and the dental mesenchymal FGF8 could be a pivotal factor in controlling the developmental pace in a non-cell-autonomous manner during mammalian odontogenesis.