Development of the pons in human fetuses
Development of the pons in human fetuses
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DOI：
10.1111/j.1741-4520.2007.00145.x
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发表时间：
2007-06-01
影响因子：
1.3
通讯作者：
Otani, Hiroki
中科院分区：
文献类型：
--
作者：
Hatta, Toshihisa;Satow, Fumio;Otani, Hiroki
通过光学显微镜对 28 例外观正常的人类胎儿进行了脑桥的形态测量和组织学研究，其冠臀长度 (CRL) 为 90 至 246 毫米，妊娠期为 13 至 28 周。将胎儿的脑干包埋在纤维胶或石蜡中，并制备横切片。脑桥在运动三叉神经核水平的内侧丘系最腹侧边缘处分为两个区域。计算脑桥背腹侧总长度、腹侧长度和背侧长度与 CRL 和胎龄之间的关系，并拟合经验公式。结果发现，腹侧部分的尺寸增加得比背侧部分更快。在目前的CRL范围内，腹侧部分占背腹侧总长度的比例本质上高于背侧部分。桥脑核中，距CRL 235 mm处，锥体束背侧出现一些细胞质丰富、核色苍白、核仁明显的大细胞。根据Weigert染色制剂，在CRL中130-140分钟处识别出三叉神经、外展神经和面神经的每个运动根中的第一有髓纤维，并且在230-235mm处识别出内侧丘系。
Morphometric and histological studies of the pons were performed by light microscopy in 28 cases of externally normal human fetuses ranging from 90 to 246 mm in crown-rump length (CRL) and from 13 to 28 weeks of gestation. The brainstems of fetuses were embedded in celloidin or paraffin, and transverse sections were prepared. The pons was divided into two regions at the most ventral margin of the medial lemniscus at the level of the motor trigeminal nucleus. The relationships between the total dorsoventral length, ventral length, and dorsal length of the pons versus CRL and gestational ages were calculated, and empiric formulas were fitted. It was found that the ventral portion increased in size more rapidly than the dorsal portion. The proportion of the ventral portion in the total dorsoventral length was constitutively higher than that of the dorsal portion in the present range of CRL. In the pontine nuclei, from 235 mm in the CRL, some large cells with rich cytoplasm, pale nuclei, and a distinct nucleolus appeared on the dorsal side of the pyramidal tract. According to Weigert stained preparations, the first myelinated fibers in each motor root of the trigeminal, abducent, and facial nerves were recognized at 130-140 min in CRL and the medial lemniscus at 230-235 mm.