AMYLOID PROTEIN SAA IS ASSOCIATED WITH HIGH-DENSITY LIPOPROTEIN FROM HUMAN-SERUM - (APOLIPOPROTEINS)
AMYLOID PROTEIN SAA IS ASSOCIATED WITH HIGH-DENSITY LIPOPROTEIN FROM HUMAN-SERUM - (APOLIPOPROTEINS)
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DOI：
10.1073/pnas.74.9.4025
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发表时间：
1977-01-01
影响因子：
11.1
通讯作者：
ERIKSEN, N
中科院分区：
文献类型：
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作者：
BENDITT, EP;ERIKSEN, N
人类血清中含有一种与AA蛋白（淀粉样蛋白的主要种类）有抗原性关系的蛋白。血清抗原SAA主要以高分子量形式出现，为1-2倍。105. 这项工作表明，SAA的大部分沉淀密度为1.12 g/cm3，漂浮密度为1.21 g/cm3，高密度脂蛋白HDL3也是如此。SAA与载脂蛋白ApoA-I和ApoA-II有关。密度为1.12-1.21 g/cm3的馏分总胆固醇：总蛋白比值为0.2:1，与HDL3一致。酸处理将HDL3馏分中SAA成分的很大一部分解离成13000量级的低MW物质。SAA的含量可以从HDL3总蛋白的0.1%到1%或更多。
Human sera contain a protein antigenically related to protein AA, the principal protein of a major class of amyloid substance. The serum antigen, SAA, occurs mainly in a high MW form, 1-2 .times. 105. This work shows that the bulk of the SAA sediments at density 1.12 g/cm3 and floats at density 1.21 g/cm3, as does the high density lipoprotein HDL3. SAA is associated with the apolipoproteins ApoA-I and ApoA-II. The total cholesterol:total protein ratio of the fraction with density 1.12-1.21 g/cm3 is 0.2:1, consistent with that of HDL3. Acid treatment dissociates a significant portion of the SAA constituent of the HDL3 fraction into low MW species of the order of 13,000. The quantity of SAA may vary from 0.1% up to 1% or more of the total protein of HDL3.