THROMBOGENIC PROPERTIES OF UNTREATED AND POLY(ETHYLENE OXIDE)-MODIFIED POLYMERIC MATRICES USEFUL FOR PREPARING INTRAARTERIAL ION-SELECTIVE ELECTRODES
THROMBOGENIC PROPERTIES OF UNTREATED AND POLY(ETHYLENE OXIDE)-MODIFIED POLYMERIC MATRICES USEFUL FOR PREPARING INTRAARTERIAL ION-SELECTIVE ELECTRODES
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DOI：
10.1021/ac00114a003
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发表时间：
1995-09-15
影响因子：
7.4
通讯作者：
MEYERHOFF, ME
中科院分区：
文献类型：
--
作者：
ESPADASTORRE, C;MEYERHOFF, ME
体外血小板粘附性研究被用来比较不同聚合物基质的血栓形成性能，这些聚合物基质可用于制备可植入的离子选择膜电极。传统的增塑聚氯乙烯和替代的聚氨酯材料(Tecoflex，Pellethane)掺入质子(十三烷基胺)和钾选择性(伐林霉素)离子载体，被证明是潜在的血栓形成。在离子选择膜中加入高相对分子质量的聚环氧乙烷和聚环氧丙烷嵌段共聚物(例如Pluronic F108和Tetronic 1508)可降低血小板粘附性。然而，当以Tecoflex为基础的膜被一层薄薄的聚环氧乙烷光交联层覆盖时，可以观察到更显著的血小板粘附性降低。这种表面改性膜保持了电位离子响应特性(即，选择性、响应时间、响应斜率等)。基本上等同于未经处理的膜。
In vitro platelet adhesion studies are used to compare the thrombogenic properties of various polymer matrices useful for preparing implantable ion-selective membrane electrodes. Conventional plasticized poly(vinyl chloride) and alternate polyurethane materials (Tecoflex, Pellethane) doped with proton- (tridodecylamine) and potassium-selective (valinomycin) ionophores are shown to be potentially thrombogenic. Incorporation of high molecular weight block copolymers of poly(ethylene oxide) and poly(propylene oxide) (e.g., Pluronic F108 and Tetronic 1508) within ion-selective membranes reduces platelet adhesion. A more marked decrease in platelet adhesion is, however, observed when the Tecoflex-based membranes are coated with a thin photo-cross-linked layer of poly(ethylene oxide). Such surface-modified membranes are shown to retain potentiometric ion response properties (i.e., selectivity, response times, response slopes, etc.) essentially equivalent to untreated membranes.