Integrating demographic and epidemiological approaches to research on HIV/AIDS: The proximate-determinants framework
Integrating demographic and epidemiological approaches to research on HIV/AIDS: The proximate-determinants framework
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DOI：
10.1086/425282
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发表时间：
2005-02-01
影响因子：
6.4
通讯作者：
Weir, SS
中科院分区：
文献类型：
--
作者：
Boerma, JT;Weir, SS
本文提出了一个概念框架的分布和人类免疫缺陷病毒（HIV）感染的决定因素在人群中的研究，结合人口学和流行病学的方法。在研究发展中国家的生育率和儿童存活率时广泛采用了近因决定因素框架。该框架的关键是确定一套称为“直接决定因素”的变量，这些变量可以受到背景变量变化或干预措施的影响，并对影响健康结果的生物机制产生直接影响。在HIV研究中，生物学机制是决定感染繁殖率的组成部分。近因决定因素框架可用于研究设计、分析和解释风险因素或包括生物和行为数据的干预研究以及生态学研究。
This article presents a conceptual framework for the study of the distribution and determinants of human immunodeficiency virus (HIV) infection in populations, by combining demographic and epidemiological approaches. The proximate-determinants framework has been applied extensively in the study of fertility and child survival in developing countries. Key to the framework is the identification of a set of variables, called "proximate determinants," that can be influenced by changes in contextual variables or by interventions and that have a direct effect on biological mechanisms to influence health outcomes. In HIV research, the biological mechanisms are the components that determine the reproductive rate of infection. The proximate-determinants framework can be used in study design, in the analysis and interpretation of risk factors or intervention studies that include both biological and behavioral data, and in ecological studies.