New human T-lymphotropic retrovirus related to simian T-lymphotropic virus type III (STLV-IIIAGM).
New human T-lymphotropic retrovirus related to simian T-lymphotropic virus type III (STLV-IIIAGM).
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与猿猴嗜 T 淋巴细胞病毒 III 型相关的新型人类嗜 T 淋巴细胞逆转录病毒 (STLV-IIIAGM)。
DOI：
10.1126/science.3006256
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Denis,F
中科院分区：
文献类型：
--
作者：
Kanki,PJ;Barin,F;M'Boup,S;Allan,JS;Romet-Lemonne,JL;Marlink,R;McLane,MF;Lee,TH;Arbeille,B;Denis,F
本报告描述了一种病毒的血清学证据，该病毒类似于非洲绿色猴嗜T淋巴细胞病毒III型（STLV-IIIAGM），感染了西非塞内加尔的健康人群，并从这些人中分离出病毒。从选定的健康西非人的血清样本显示不寻常的血清学特征时，测试抗原的HTLV-III/LAV，艾滋病的病原体，和STLV-IIIAGM。用放射免疫沉淀法和十二烷基硫酸钠-聚丙烯酰胺凝胶电泳法测定，样品与STLV-IIIAGM的所有主要病毒抗原均呈强反应，但与HTLV-III/LAV的主要病毒抗原呈可变反应或不反应。从这些人中分离的一种新的人类嗜T淋巴细胞病毒（HTLV-IV）在体外生长，并显示具有逆转录病毒型颗粒，生长特征和主要病毒蛋白类似于STLV-III和HTLV-III/LAV组逆转录病毒。沉淀的gp 120/160、gp 32、p64、p55、p53、p24和p15蛋白与STLV-IIIAGM蛋白大小相同，并与STLV-IIIAGM蛋白反应。血清学数据表明，该病毒与STLV-IIIAGM比与感染美国和欧洲人群的原型HTLV-III/LAV共享更多的共同表位。进一步研究这种病毒和HTLV-III/LAV病毒组的起源可能会扩大我们对人类艾滋病病毒的理解。
This report describes serologic evidence for a virus similar to that known as simian T-lymphotropic virus type III of African Green monkeys (STLV-IIIAGM) infecting apparently healthy people in Senegal, West Africa, and the isolation of virus from these individuals. Serum samples from selected healthy West African people showed unusual serologic profiles when tested with antigens of HTLV-III/LAV, the etiologic agent of AIDS, and of STLV-IIIAGM. The samples reacted strongly with all of the major viral antigens of STLV-IIIAGMbut showed variable or no reactivity with the major viral antigens of HTLV-III/LAV by radioimmunoprecipitation and sodium dodecyl sulfate-polyacrylamide gel electrophoresis. A new human T-lymphotropic virus (HTLV-IV) isolated from these people was grown in vitro and shown to have retroviral type particles, growth characteristics, and major viral proteins similar to those of the STLV-III and HTLV-III/LAV group of retroviruses. The gp120/160, gp32, p64, p55, p53, p24, and p15 proteins precipitated were the same size as and reactive with STLV-IIIAGMproteins. The serologic data suggest that this virus shares more common epitopes with STLV-IIIAGMthan with the prototype HTLV-III/LAV that infects people in the United States and Europe. Further study of this virus and of the origin of the HTLV-III/LAV group of viruses may expand our understanding of the human AIDS virus.