Population stratification in the candidate gene study: Fatal threat or red herring?
Population stratification in the candidate gene study: Fatal threat or red herring?
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DOI：
10.1037/0033-2909.130.1.66
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发表时间：
2004-01-01
影响因子：
22.4
通讯作者：
Bryan, A
中科院分区：
文献类型：
--
作者：
Hutchison, KE;Stallings, M;Bryan, A
分子遗传学的进展为行为科学家提供了一种研究遗传因素对人类行为影响的手段。不幸的是最近的候选基因研究产生了不一致的结果，而缺乏跨研究复制的一个常见的替罪羊是人口分层的威胁。这篇关于人口分层的文献综述表明，这种威胁可能是一种转移注意力的东西。可靠的研究结果将需要改进的规范和测量的行为表型的问题，重新关注内部效度，并在纵向多变量模型的背景下的遗传因素的规范和测试。在这方面，行为科学家非常适合研究影响心理机制的遗传因素。
Advances in molecular genetics have provided behavioral scientists with a means of investigating the influence of genetic factors on human behavior. Unfortunately. recent candidate gene studies have produced inconsistent results, and a frequent scapegoat for the lack of replication across studies is the threat of population stratification. This review of the literature on population stratification suggests that the threat may be a red herring. Reliable findings will require improved specification and measurement of the behavioral phenotypes in question, a renewed focus on internal validity, and the specification and testing of genetic factors in the context of longitudinal multivariate models. In this respect, behavioral scientists are well suited to investigating genetic factors that influence psychological mechanisms.