Risk of childhood leukemia associated with parental smoking and alcohol consumption prior to conception and during pregnancy: the cross-Canada childhood leukemia study
Risk of childhood leukemia associated with parental smoking and alcohol consumption prior to conception and during pregnancy: the cross-Canada childhood leukemia study
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DOI：
10.1007/s10552-007-9091-8
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发表时间：
2008-04-01
影响因子：
2.3
通讯作者：
Theriault, Gilles
中科院分区：
文献类型：
--
作者：
MacArthur, Amy C.;McBride, Mary L.;Theriault, Gilles
目的作为一个更大的病例对照研究的一部分，作者评估了儿童白血病的风险相对于父母自我报告的吸烟和饮酒consumption.Methods儿童0 - 14岁之间诊断为白血病1990年和1994年被确定通过人口为基础的来源在诊断时。对于每个参与病例，从省政府健康保险卷中随机选择年龄，性别和地区匹配的对照。通过与每个孩子的父母进行个人访谈获得风险因素信息。采用条件Logistic回归模型分析父母吸烟和饮酒与白血病发病的关系。（OR = 1.37，95%CI，0.99 - 1.90）和妊娠期间（OR = 1.39，95%CI，1.01 - 1.93）与儿童白血病的过度风险相关，每周摄入量增加呈阳性剂量反应趋势（p <0.05）。在诊断为急性淋巴细胞白血病（ALL）的儿童中观察到类似的结果。母亲在怀孕前和怀孕期间吸烟的优势比一直高于1，但没有统计学意义。没有观察到与父亲饮酒或吸烟在围产期periods.Conclusion我们的研究表明，母亲饮酒前或怀孕期间可能有助于儿童白血病的风险增加。
Objective As part of a larger case-control study, the authors evaluated risk of childhood leukemia relative to parental self-reported smoking and alcohol consumption.Methods Children 0-14 years of age diagnosed with leukemia between 1990 and 1994 were ascertained through population-based sources at the time of diagnosis. For each participating case, an age, gender, and area-matched control was randomly selected from provincial government health insurance rolls. Risk factor information was obtained through personal interviews with each child's parents. Conditional logistic regression models were used to examine risk of leukemia associated with parental smoking and drinking.Results Maternal alcohol consumption prior to conception (OR = 1.37, 95% CI, 0.99-1.90) and during pregnancy (OR = 1.39, 95% CI, 1.01-1.93) was associated with an excess risk of childhood leukemia, with a positive dose-response trend for increasing weekly consumption (p< 0.05). Similar results were observed for children diagnosed with acute lymphoblastic leukemia (ALL). Odds ratios for maternal cigarette smoking before and during pregnancy were consistently elevated above one, but not statistically significant. No relationship was observed with paternal drinking or smoking in the perinatal period.Conclusion Our study suggests that maternal alcohol drinking before or during pregnancy may contribute to an increased risk of childhood leukemia.