RISK-FACTORS FOR PENILE CANCER - RESULTS FROM A CASE-CONTROL STUDY IN CHINA
RISK-FACTORS FOR PENILE CANCER - RESULTS FROM A CASE-CONTROL STUDY IN CHINA
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DOI：
10.1002/ijc.2910470406
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发表时间：
1991-02-20
影响因子：
6.4
通讯作者：
DAWSEY, S
中科院分区：
文献类型：
--
作者：
BRINTON, LA;LI, JY;DAWSEY, S
对中国高发区14 1例阴茎癌患者和15 0名社区对照进行了阴茎癌流行病学调查。个人面谈以及在预期确定的受试者中进行体检，使得能够评估各种潜在的风险因素。与风险密切相关的是限制包皮活动的条件，包括包茎或包皮异常，特别是当包皮严重到需要进行包皮环切术治疗的时候。不良的卫生习惯似乎也增加了风险，特别是在体检中发现污垢，尽管很难破译这种联系是病因还是仅仅是疾病的结果。婚外性关系与RR为1.7相关，而且似乎是比终身性伴侣数量更重要的歧视因素。在报告既往生殖器疾病，特别是性传播疾病的受试者中，风险增加，体检显示13例患者与1名对照组相比出现生殖器疣。对研究对象妻子的采访未能提供阴茎癌病因学中“女性因素”的证据。这项研究支持进一步评估卫生和性传播因素在阴茎癌病因中的作用的必要性。
An epidemiologic study of penile cancer involving 141 cases and 150 community controls was undertaken in a high-risk area in China. Personal interviews, as well as physical examinations among the prospectively ascertained subjects, enabled evaluation of a variety of potential risk factors. Strongly related to risk were conditions restricting the motility of the foreskin, including phimosis or paraphimosis, particularly when so severe that circumcision was used for treatment. Poor hygiene practices also appeared to increase risk, particularly as evidenced by detection of smegma on physical examination, although it was difficult to decipher whether this association was etiologic or merely a consequence of disease. A sexual relationship outside of marriage was associated with a RR of 1.7, and appeared to be a more important discriminator than number of lifetime sexual partners. Risk was increased among subjects reporting previous genital conditions, particularly sexually transmitted diseases, and physical examinations revealed the appearance of genital warts among 13 cases vs. 1 control. Interviews with wives of study subjects failed to provide evidence of a "female factor" in the etiology of penile cancer. This study supports the need for further evaluation of the role of hygiene and sexually transmitted agents in the etiology of penile cancer.