CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells
CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells
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DOI：
10.1073/pnas.96.25.14470
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发表时间：
1999-12-07
影响因子：
11.1
通讯作者：
Zlotnik, A
中科院分区：
文献类型：
--
作者：
Morales, J;Homey, B;Zlotnik, A
与幼稚淋巴细胞相反，记忆/效应淋巴细胞可以进入非淋巴效应子，并显示出有限的，通常是组织选择性的迁移行为。皮肤淋巴细胞相关抗原（CLA）定义了一个循环记忆T细胞的子集，其选择性地定位于皮肤部位，部分介导：通过CLA与其血管配体E-选择素的相互作用。在这里，我们报告的CC趋化因子，皮肤T细胞吸引趋化因子（CTACK）的鉴定和表征，人类和小鼠的CTACK检测仅在皮肤中的Southern和北方印迹分析。具体而言，CTACK信息存在于小鼠表皮和人角质形成细胞中，并且抗CTACK mAb主要染色上皮。最后，CTACK选择性地吸引CLA（+）记忆T细胞。总之，这些结果表明CTACK在招募CLA（+）T细胞到皮肤部位中起重要作用。CTACK主要在皮肤中表达，并选择性地吸引记忆淋巴细胞的组织特异性亚群。
In contrast to naive lymphocytes, memory/effector lymphocytes can access nonlymphoid effector sires and display restricted, often tissue-selective, migration behavior. The cutaneous lymphocyte-associated antigen (CLA) defines a subset of circulating memory T cells that selectively localize in cutaneous sites mediated in part: by the interaction of CLA with its vascular ligand E-selectin. Here, we report the identification and characterization of a CC chemokine, cutaneous T cell-attracting chemokine (CTACK), Both human and mouse CTACK are detected only in skin by Southern and Northern blot analyses. Specifically, CTACK message is found in the mouse epidermis and in human keratinocytes, and anti-CTACK mAbs predominantly stain the epithelium. Finally, CTACK selectively attracts CLA(+) memory T cells. Taken together, these results suggest an important role for CTACK in recruitment of CLA(+) T cells to cutaneous sites. CTACK is predominantly expressed in the skin and selectively attracts a tissue-specific subpopulation of memory lymphocytes.