Revisiting the source of candidemia: Skin or gut?
Revisiting the source of candidemia: Skin or gut?
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DOI：
10.1086/323759
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发表时间：
2001-12-15
影响因子：
11.8
通讯作者：
Anaissie, E
中科院分区：
文献类型：
--
作者：
Nucci, M;Anaissie, E
念珠菌的来源一直是争论不休的话题，一些人认为它起源于胃肠道，另一些人认为它起源于皮肤。为了评估念珠菌的潜在来源，我们对MEDLINE数据库进行了计算机检索，检索了1966年1月至2000年9月期间发表的研究，并确定了在国家会议上发表的相关摘要。我们回顾了文献，特别强调了使用适当定义的研究，评估了肠道和皮肤作为来源，并进行了分子相关性研究。在已发表的203篇念珠菌研究中，我们发现21篇评估了念珠菌的特定来源，只有5篇进行了分子分型。这些研究以及其他实验、流行病学和分子相关性研究强烈表明，肠道是念珠菌的重要来源，而支持皮肤作为这种感染来源的研究令人惊讶地不完整。
The source of candidemia has been the subject of considerable debate, with some suggesting a origin in the gastrointestinal tract and others suggesting a skin origin. To evaluate the potential sources of candidemia, we performed a computerized search of the MEDLINE database for studies published from January 1966 through September 2000 and we identified relevant abstracts presented at national meetings. We reviewed the literature with special emphasis on studies that used appropriate definitions, evaluated both gut and skin as sources, and conducted molecular-relatedness studies. Among 203 candidemia studies published, we identified 21 that evaluated a specific source for candidemia and only 5 that performed molecular typing. Those studies and additional experimental, epidemiologic, and molecular-relatedness studies strongly suggested that the gut is an important source of candidemia, and studies that supported the skin as a source for this infection were surprisingly incomplete.