Polymorphisms of the formylpeptide receptor gene (FPR1) and susceptibility to stomach cancer in 1531 consecutive autopsy cases.
Polymorphisms of the formylpeptide receptor gene (FPR1) and susceptibility to stomach cancer in 1531 consecutive autopsy cases.
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DOI：
10.1016/j.bbrc.2010.12.136
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发表时间：
2011-02
影响因子：
3.1
通讯作者：
T. Otani;S. Ikeda;H. Lwin;T. Arai;M. Muramatsu;M. Sawabe
中科院分区：
文献类型：
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作者：
T. Otani;S. Ikeda;H. Lwin;T. Arai;M. Muramatsu;M. Sawabe
甲酰基肽受体（FPR 1）参与炎症，这在包括常见疾病和癌症在内的多种疾病的发病机制中很重要。迄今为止，人们对FPR 1与这些疾病之间的关系知之甚少，除了FPR 1与牙周炎有关的事实之外，牙周炎与胃癌等全身性疾病有关。我们假设FPR 1基因多态性与牙周病相关，可能赋予胃癌的易感性。分析了1531例日本老年人连续尸检病例中甲酰肽受体基因第二胞外区和C末端的两个单核苷酸多态性（SNP）。采用改良熔解温度分析法检测rs 1042229位点的三等位基因SNP。rs 1042229的纯合子K等位基因与胃癌相关（比值比[OR]=1.62，置信区间[CI]=1.05-2.48，p=0.028）。在K等位基因的隐性模型分析中，FPR 1与胃癌的高风险相关（OR=1.73，CI=1.15-2.55，p=0.0075）。胃癌的危险等位基因与牙周炎的危险等位基因指向相同的方向。这是第一项评估胃癌中FPR 1基因多态性的研究，以发现这些多态性与胃癌之间的正相关性。FPR 1基因与胃癌的关系有待进一步研究。
Formylpeptide receptor (FPR1) is involved in inflammation, which is important in the pathogenesis of diverse conditions, including common diseases and cancers. To date, little is known about the relationships between FPR1 and such diseases, aside from the fact that FPR1 is related to periodontitis, which is implicated in systemic diseases such as stomach cancer. We hypothesized that FPR1 polymorphisms related to periodontal disease may confer susceptibility to stomach cancer. Two single nucleotide polymorphisms (SNPs) in the second extracellular region and C-terminus of the formylpeptide receptor gene were analyzed in 1531 consecutive autopsy cases in the Japanese elderly. The tri-allelic SNP of rs1042229 was detected by modified melting temperature analysis. Homozygous K alleles of rs1042229 were associated with stomach cancer (Odds ratio [OR]=1.62, confidence interval [CI]=1.05–2.48, p=0.028). In the analysis of the recessive model of the K allele, FPR1 was associated with a high risk of stomach cancer (OR=1.73, CI=1.15–2.55, p=0.0075). The risk allele for stomach cancer pointed in the same direction as periodontitis. This is the first study to evaluate polymorphisms of the FPR1 gene in stomach cancer to find a positive association between these polymorphisms and stomach cancer. Further studies on the relationship between stomach cancer and the FPR1 gene are warranted.