Protective effects of resveratrol on acute kidney injury in rats with sepsis
Protective effects of resveratrol on acute kidney injury in rats with sepsis
复制标题
白藜芦醇对脓毒症大鼠急性肾损伤的保护作用
DOI：
10.5507/bp.2019.006
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发表时间：
2020-03-01
影响因子：
0.9
通讯作者：
Xu, Yan
中科院分区：
文献类型：
--
作者：
Luo, Cong-Juan;Luo, Feng;Xu, Yan
Aim. To evaluate the protective effects of resveratrol on acute kidney injury (AKI) in septic rats.Methods. A septic rat model was established by cecal ligation and puncture (CLP). A total of 108 male Sprague Dawley rats were randomly divided into an observation group, a 6 h resveratrol intervention group and a 12 h resveratrol intervention group. Then each group was subdivided into Sham, Sham + Res, CLP and CLP + Res groups. After surgery, the survival and morphological changes in kidney tissues were observed. Serum creatinine and urea nitrogen levels, expression of GRP78, BiP, IRE1 and p65 in kidney tissues, and serum levels of TNF-alpha, IL-1 beta, IL-6 and IL-10 were investigated.Results. The survival rate of CLP + Res group (75.00%) significantly exceeded that of the CLP group (41.67%) (P
