Prevalence of Hepatitis B Virus (HBV) Among Blood Donors in Eastern Saudi Arabia: Results From a Five-Year Retrospective Study of HBV Seromarkers
Prevalence of Hepatitis B Virus (HBV) Among Blood Donors in Eastern Saudi Arabia: Results From a Five-Year Retrospective Study of HBV Seromarkers
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DOI：
10.3343/alm.2019.39.1.81
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发表时间：
2019-01-01
影响因子：
4.9
通讯作者：
Elhadi, Nasreldin
中科院分区：
文献类型：
--
作者：
Alzahrani, Faisal Mousa;Muzaheed;Elhadi, Nasreldin
背景：输血传播的乙肝病毒感染是一个世界性的重大问题。最近，HBVDNA的确认性核酸测试(NAT)已经在几个国家得到了应用。我们评估了沙特阿拉伯东部省份献血者中乙肝病毒感染的患病率和年度趋势，筛查了乙肝表面抗原(HBs)、抗乙肝核心抗原抗体(抗-HBc)和HBVDNA。方法：2011至2015年间，共有22,842名献血者使用HBs Ag定性II试剂盒(Abbott，爱尔兰诊断部，斯莱戈)、建筑师抗乙肝核心抗原抗体(HBC)II试剂盒(Abbott GmbH&Co.kg，德国威斯巴登)和Nat Procleix Ultrio Elite Assay Kit(Grifols Diagnostics Inc.，洛杉矶，CA，CA)进行了乙肝表面抗原、抗-HBc和HBVDNA筛查。结果：739例(3.24%)献血者为HBs Ag(+)、抗-HBc(+)或HBVDNA(+)；HBs Ag、抗-HBc、HBVdna阳性63例(0.28%)。抗-HBc(+)、HBVdna(+)、HBs Ag(-)阳性12例(0.05%)，均为隐匿性感染。HBs Ag阴性而抗-HBc阳性者664例(2.91%)，提示慢性或消退感染。从2011年到2012年，献血员的乙肝病毒感染率显著上升，直到2013年，感染率略有上升，自2013年起呈下降趋势(P>；0.05)。结论：沙特阿拉伯东部省份献血员的5年感染率(3.24%)低于该国其他地区的报告。0.05%的隐匿性乙肝病毒感染率强调了NAT在分离潜在感染血液单位方面的重要性。
Background: Transfusion-transmissible hepatitis B virus (HBV) infection is a major problem worldwide. Recently, confirmatory nucleic acid tests (NATs) for HBV DNA have been employed in several countries. We assessed the prevalence and yearly trends of HBV infection in blood donors in the Eastern Province of Saudi Arabia, screening for HBV surface antigen (HBsAg), antibody against HBV core antigen (anti-HBc), and HBV DNA.Methods: Between 2011 and 2015, a total of 22,842 donors were screenedfor HBsAg, anti-HBc, and HBV DNA using the HBsAg Qualitative II kit (Abbott, Ireland Diagnostics Division, Sligo, Ireland), ARCHITECT Anti-hepatitis B core antigen antibody (HBc) II Assay kit (Abbott GmbH & Co. KG, Wiesbaden, Germany), and NAT Procleix Ultrio Elite Assay kit (Grifols Diagnostic Solutions Inc., Los Angeles, CA, USA), respectively.Results: A total of 739 (3.24%) donors were HbsAg(+), anti-HBc(+), or HBV DNA(+); 63 (0.28%) were HbsAg(+), anti-HBc(+), and HBV DNA(+). Twelve (0.05%) were anti-HBc(+) and HBV DNA(+) but HBsAg(-); they were considered to have occult infection. Further, 664 (2.91%) were HBsAg(-) but anti-HBc(+), indicating chronic or resolving infection. HBV prevalence increased significantly from 2011 to 2012, increased marginally till 2013, and showed a decreasing trend from 2013 (P > 0.05).Conclusions: The five-year prevalence of HBV infection among blood donors in the Eastern Province of Saudi Arabia (3.24%) is lower than that reported for other regions in the country. The occult HBV infection rate of 0.05% emphasizes the importance of NATs in isolating potential infectious blood units.