Predictors, consequences and costs of diabetes-related lower extremity amputation complicating type 2 diabetes: The Fremantle Diabetes Study
Predictors, consequences and costs of diabetes-related lower extremity amputation complicating type 2 diabetes: The Fremantle Diabetes Study
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DOI：
10.1007/s00125-006-0431-0
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发表时间：
2006-11-01
期刊：
影响因子：
8.2
通讯作者：
Davis, T. M. E.
中科院分区：
文献类型：
--
作者：
Davis, W. A.;Norman, P. E.;Davis, T. M. E.
目的/假设本研究的目的是评估社区2型糖尿病患者下肢截肢（LEA）的发生率、预测因素、后果和住院费用。方法1993年至1996年间，1294例2型糖尿病患者被纳入纵向观察性Fremantle糖尿病研究。到2005年6月30日为止，一直监测呼吸衰竭和心脏病死亡率。1993年7月1日至2000年6月30日期间的住院费用（按2000年澳元计算）是采用病例混合方法得出的。结果在随访期间，44例基线时无LEA的患者首次出现糖尿病相关LEA，发生率为3.8 / 1000患者年。首次LEA的独立预测因素包括足部溃疡（风险比[95% CI]: 5.56[1.24-25.01]）、踝肱指数
Aims/hypothesis The aims of this study were to assess the incidence, predictors, consequences, and inpatient cost of lower extremity amputation (LEA) in a community-based cohort of type 2 diabetic patients.Methods Between 1993 and 1996, 1,294 patients with type 2 diabetes were recruited to the longitudinal, observational Fremantle Diabetes Study. LEAs and mortality from cardiac causes were monitored until 30 June 2005. Inpatient costs (in A$ in year 2000), derived using a case-mix approach, were available for the period from 1 July 1993 to 30 June 2000.Results During follow-up 44 patients without LEA at baseline had a first-ever diabetes-related LEA, an incidence of 3.8 per 1,000 patient-years. Independent predictors of first-ever LEA included foot ulceration (hazard ratio [95% CI]: 5.56 [1.24-25.01]), an ankle brachial index