Coincidental association of mycosis fungoides and occupational systemic sclerosis?
Coincidental association of mycosis fungoides and occupational systemic sclerosis?
复制标题
蕈样肉芽肿与职业性系统性硬化症有巧合吗？
DOI：
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发表时间：
2007
期刊：
影响因子：
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通讯作者：
O. Ishikawa
中科院分区：
文献类型：
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作者：
M. Yasuda;H. Amano;Masayoshi Yamanaka;A. Tamura;O. Ishikawa
我们报告一例58岁男性真菌病（MF）和职业性系统性硬化症（SSc）由二氧化硅暴露引起。他从18岁到33岁一直从事隧道施工。他在30岁时患上了MF。52岁诊断为矽肺病，58岁诊断为SSc。体格检查发现他的前臂和手指皮肤硬化改变，左腘窝和腹股沟区域有千皮病。抗核抗体和抗拓扑异构酶ⅰ抗体均为阳性。我们发现他的临床特征与特发性SSc没有明显的区别，除了有矽肺和MF的存在。干扰素γ对MF的全身治疗没有改善皮肤硬化。我们讨论了二氧化硅暴露于MF和SSc的关系。
We report a 58‐year‐old man with mycosis fungoides (MF) and occupational systemic sclerosis (SSc) induced by silica exposure. He was engaged in tunnel construction from the age of 18 to 33 years. He developed MF at the age of 30. Diagnosis of silicosis was made at the age of 52 and SSc at the age of 58. Physical examinations revealed sclerotic skin changes on his forearms and fingers and poikiloderma on the left popliteal fossa and inguinal region. Both antinuclear antibody and antitopoisomerase‐I antibody were positive. We could find no apparent difference between his clinical features and those of idiopathic SSc except for the presence of silicosis and MF. Systemic therapy with interferon‐γ for MF did not improve the skin sclerosis. We discuss the relationship of silica exposure to both MF and SSc.