Levels of serum-circulating angiogenic factors within 1 week prior to delivery are closely related to conditions of pregnant women with pre-eclampsia, gestational hypertension, and/or fetal growth restriction
Levels of serum-circulating angiogenic factors within 1 week prior to delivery are closely related to conditions of pregnant women with pre-eclampsia, gestational hypertension, and/or fetal growth restriction
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DOI：
10.1111/jog.13452
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发表时间：
2017-12-01
影响因子：
1.6
通讯作者：
Ino, Kazuhiko
中科院分区：
文献类型：
--
作者：
Nanjo, Sakiko;Minami, Sawako;Ino, Kazuhiko
AimWe旨在探讨孕妇血清血管生成标记物的情况下，妊娠高血压（GH），先兆子痫（PE），和/或胎儿生长受限（FGR）与不同的临床conditions.MethodsWe纳入165例单胎妊娠妇女分娩前1周内。根据三个特征对参与者进行分类：（i）蛋白尿（GH和PE）;（ii）FGR（PE伴FGR [PE + FGR]、单独PE和单独FGR）;和（iii）发作（早发性PE [EO PE]和晚发性PE [LO PE]）。结果（1）PE组sFlt-1、sEng及sFlt-1/PlGF比值均显著高于对照组（P < 0. 05），sEng及sFlt-1/PlGF比值均显著高于对照组（P < 0. 05），sEng及sFlt-1/PlGF比值均显著高于对照组（P < 0. 05）。与GH和Term对照相比，观察到sFlt-1/PlGF和PlGF显著降低，而在GH中，仅sFlt-1/PlGF显著高于Term对照。(ii)PE + FGR组与单纯PE组相比，上述变化更为明显。单独FGR组表现出与PE相似的趋势，尽管在PlGF和sEng水平上发现了显著差异。(iii)在EO PE，观察到显着的变化，在所有因素与LO PE或长期控制相比，而没有显着的变化，在PLGF水平之间观察到LO PE和长期control.ConclusionWe表明，循环血管生成因子的水平在分娩前与妊娠期高血压疾病和FGR的严重程度。分析这些特异性标志物可能有助于更好地了解个体患者的临床状况及其发病机制。
AimWe aimed to investigate maternal serum angiogenic marker profiles within 1 week prior to delivery in cases of gestational hypertension (GH), pre-eclampsia (PE), and/or fetal growth restriction (FGR) with different clinical conditions.MethodsWe enrolled 165 women with singleton pregnancy. The participants were classified based on three characteristics: (i) proteinuria (GH and PE); (ii) FGR (PE with FGR [PE + FGR], PE alone, and FGR alone); and (iii) onset (early onset PE [EO PE] and late-onset PE [LO PE]). All sera were obtained within 1 week prior to delivery, and soluble fms-like tyrosine kinase 1 (sFlt-1), soluble endoglin (sEng), and placental growth factor (PlGF) were measured with enzyme-linked immunosorbent assay.Results(i) In PE, a significantly increased sFlt-1, sEng, and sFlt-1 to PlGF ratio (sFlt-1/PlGF) and significantly decreased PlGF were observed compared with GH and Term control, whereas in GH, only sFlt-1/PlGF was significantly higher than Term control. (ii) In PE + FGR, similar changes were more markedly shown compared with PE alone. The FGR alone group exhibited similar tendencies as PE, although significant differences were found in PlGF and sEng levels. (iii) In EO PE, significant changes were observed in all factors compared with LO PE or Term control, while no significant change in PlGF levels was observed between LO PE and Term control.ConclusionWe demonstrated that the levels of circulating angiogenic factors just before delivery are correlated with the severity of hypertensive disorders of pregnancy and FGR. Profiling these specific markers may contribute to better understanding of the clinical conditions in individual patients and their pathogenesis.