CXCR2-positive neutrophils are essential for cuprizone-induced demyelination: relevance to multiple sclerosis.
CXCR2-positive neutrophils are essential for cuprizone-induced demyelination: relevance to multiple sclerosis.
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DOI：
10.1038/nn.2491
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发表时间：
2010-03
影响因子：
25
通讯作者：
Ransohoff, Richard M.
中科院分区：
文献类型：
--
作者：
Liu, LiPing;Belkadi, Abdelmadjid;Darnall, Lindsey;Hu, Taofang;Drescher, Caitlin;Cotleur, Anne C.;Padovani-Claudio, Dolly;He, Tao;Choi, Karen;Lane, Thomas E.;Miller, Robert H.;Ransohoff, Richard M.
多发性硬化（MS）是中枢神经系统（CNS）的炎性脱髓鞘疾病。最近的研究表明，脱髓鞘的各种机制，包括一个子集的病变涉及代谢损伤少突胶质细胞和炎症介质之间的相互作用。对于敏感品系的小鼠，喂食铜腙导致少突胶质细胞损失和胼胝体脱髓鞘。再髓鞘化增强，并已被广泛研究。铜蛋白引起的脱髓鞘仍然不完全的特点。在这里，我们表明，小鼠缺乏2型CXC趋化因子受体（CXCR2）是相对耐铜唑酮诱导的脱髓鞘，和CXCR2+中性粒细胞从循环中发挥重要作用，铜唑酮诱导的脱髓鞘。研究结果支持一种新的二次打击过程的铜蛋白诱导的脱髓鞘，反映了建议的发病机制的MS病变，具有广泛的少突胶质细胞损失。这些数据表明，cuprizone诱导的脱髓鞘将提供一个有用的模型MS发病机制的某些方面。
Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system (CNS). Recent studies suggest diverse mechanisms underlying demyelination, including a subset of lesions involving interplay between metabolic insult to oligodendrocytes and inflammatory mediators. For mice of susceptible strains, cuprizone feeding results in oligodendrocyte cell loss and demyelination of the corpus callosum. Remyelination ensues, and has been extensively studied. Cuprizone-induced demyelination remains incompletely characterized. Here we show that mice lacking type 2 CXC chemokine receptor (CXCR2) are relatively resistant to cuprizone-induced demyelination, and CXCR2+ neutrophils from the circulation play an essential role in cuprizone-induced demyelination. Findings support a novel two-hit process of cuprizone-induced demyelination, mirroring proposals about pathogenesis of MS lesions featuring extensive oligodendrocyte cell loss. These data indicate that cuprizone-induced demyelination will provide a useful model for certain aspects of MS pathogenesis.
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影响因子：
11.2
作者：
Fuller, Molly L.;DeChant, Anne K.;Miller, Robert H.
通讯作者：
Miller, Robert H.
DOI：
10.1093/jnen/63.3.262
发表时间：
2004-03-01
影响因子：
3.2
作者：
Mahad, DJ;Trebst, C;Ransohoff, RM
通讯作者：
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影响因子：
14.5
作者：
Lucchinetti, C;Brück, W;Lassmann, H
通讯作者：
Lassmann, H
影响因子：
3.5
作者：
Gao, X;Gillig, TA;Popko, B
通讯作者：
Popko, B
影响因子：
4.4
作者：
Liu, LiPing;Huang, DeRen;Ransohoff, Richard M.
通讯作者：
Ransohoff, Richard M.