Adiponectin and inducible ischemia in patients with stable coronary heart disease: data from the Heart and Soul study
Adiponectin and inducible ischemia in patients with stable coronary heart disease: data from the Heart and Soul study
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DOI：
10.1016/j.atherosclerosis.2008.11.014
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发表时间：
2009-07-01
期刊：
影响因子：
5.3
通讯作者：
Whooley, Mary A.
中科院分区：
文献类型：
--
作者：
Zhang, Mary H.;Spies, Christian;Whooley, Mary A.
目的：脂联素浓度升高与有利的代谢状况有关，但也与不利的心血管结局有关。这种明显的差异引发了关于脂联素是否与冠心病（CHID）风险增加或降低相关的问题。我们试图确定高脂联素水平是否与稳定型冠心病患者运动引起的缺血有关。方法和结果：在一项有记录的899例稳定型冠心病门诊患者的横断面研究中，我们测量了血清总脂联素浓度，并通过应激超声心动图评估了运动引起的缺血。其中诱导性缺血217例（24%）。虽然脂联素水平与糖尿病患病率、体重指数、血清胰岛素、空腹血糖、低密度脂蛋白胆固醇和甘油三酯呈负相关，但与高密度脂蛋白胆固醇呈正相关
Objective: Elevated concentrations of adiponectin are associated with a favorable metabolic profile but also with adverse cardiovascular outcomes. This apparent discrepancy has raised questions about whether adiponectin is associated with an increased or decreased risk of coronary heart disease (CHID). We sought to determine whether higher adiponectin levels are associated with exercise-induced ischemia in patients with stable CHD.Methods and results: We measured total serum adiponectin concentrations and evaluated exercise-induced ischemia by stress echocardiography in a cross-sectional study of 899 outpatients with documented stable CHID. Of these, 217 (24%) had inducible ischemia. Although adiponectin levels correlated negatively with diabetes prevalence, body mass index, serum insulin, fasting glucose, low-density lipoprotein cholesterol, and triglycerides and positively with high-density lipoprotein cholesterol (all P