Age, neurofibrillary changes, A beta-amyloid and the onset of Alzheimer's disease
Age, neurofibrillary changes, A beta-amyloid and the onset of Alzheimer's disease
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DOI：
10.1016/0304-3940(96)12668-9
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发表时间：
1996-05-31
影响因子：
2.5
通讯作者：
Reintjes, R
中科院分区：
文献类型：
--
作者：
Braak, H;Braak, E;Reintjes, R
神经元内神经原纤维改变和细胞外A β -淀粉样蛋白沉积是阿尔茨海默病的神经病理学标志。对许多非选择的尸检病例的检查表明，它们绝不是大脑衰老的正常伴随物。相反，最初的神经原纤维变化表明阿尔茨海默病的开始。一小部分病例表现出特别早期的神经元内变化，表明高龄不是病变发展的先决条件。然而，特定神经原纤维病理发展的平均阶段随着年龄的增长而增加。因此，阿尔茨海默病是一种与年龄相关的疾病，而不是与年龄相关的疾病。
Intraneuronal neurofibrillary changes and extracellular A beta-amyloid deposits are neuropathologic hallmarks of Alzheimer's disease. Examination of numerous non-selected autopsy cases demonstrates that they are by no means normal concomitants of brain aging. Rather, the initial neurofibrillary changes indicate the beginning of Alzheimer's disease. A small proportion of cases displays particularly early development of the intraneuronal changes, indicating that advanced age is not a prerequisite for the evolution of the lesions. However, the mean of stages in the development of the specific neurofibrillary pathology increases with age. Alzheimer's disease is thus an age-related, not an age-dependent disease.