Metals ions and neurodegeneration
Metals ions and neurodegeneration
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DOI：
10.1007/s10534-006-9033-z
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发表时间：
2007-06-01
期刊：
影响因子：
3.5
通讯作者：
Francis, Paul
中科院分区：
文献类型：
--
作者：
Molina-Holgado, Francisco;Hider, Robert C.;Francis, Paul
神经退行性疾病包括多种病理状态，它们具有相似的关键代谢过程，如蛋白质聚集和氧化应激，这两者都与金属离子的参与有关。在这篇综述中，主要讨论了阿尔茨海默病和帕金森氏病，目的是确定这些神经疾病的共同趋势。螯合疗法可能是一种有价值的治疗方法，因为金属被认为是治疗神经退行性变的新治疗剂的基本设计的药理靶点。
Neurodegenerative disorders include a variety of pathological conditions, which share similar critical metabolic processes such as protein aggregation and oxidative stress, both of which are associated with the involvement of metal ions. In this review Alzheimer's disease and Parkinson's disease are mainly discussed, with the aim of identifying common trends underlying these neurological conditions. Chelation therapy could be a valuable therapeutic approach, since metals are considered to be a pharmacological target for the rationale design of new therapeutic agents directed towards the treatment of neurodegeneration.