Prevalence of HIV and syphilis infections among pregnant women attending antenatal clinics in Tanzania, 2011
Prevalence of HIV and syphilis infections among pregnant women attending antenatal clinics in Tanzania, 2011
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DOI：
10.1186/s12889-015-1848-5
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发表时间：
2015-05-22
影响因子：
4.5
通讯作者：
Matee, Mecky I.
中科院分区：
文献类型：
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作者：
Manyahi, Joel;Jullu, Boniphace S.;Matee, Mecky I.
背景资料：由于母婴传播，怀孕期间感染艾滋病毒-1和梅毒对胎儿的健康构成重大风险。2011年对坦桑尼亚大陆21个地区的133名产前检查孕妇进行HIV和梅毒感染监测。在每个地区，选择了六个产前护理点，城市、半城市和农村地区各提供两个。所有在2011年9月至12月期间首次在选定的哨兵ANC研究中心进行妊娠的孕妇均入组。在常规梅毒检测后，使用干血斑（DBS）以非关联匿名方式进行系列ELISA检测以检测HIV感染。使用Stata v.12软件进行数据分析。结果：共有39 698名孕妇参加了坦桑尼亚大陆ANC的所有孕妇（168万）的2.4%。总体艾滋病毒感染率为5.6%（95% CI：5.4-5.8%）。在25- 3 - 4岁（cOR = 1.97，95% CI：1.79-2.16; p < 0.05）、35岁以上（cOR = 1.88，95% CI：1.62-2.17; p < 0.05）和既往妊娠1-2次和3-4次的妇女中，艾滋病毒感染的风险显著较高。在农村产前保健诊所就诊的妇女中，艾滋病毒感染率较低（cOR = 0.46，95%CI 0.4-0.52; p < 0.05）。总梅毒患病率为2.5%（95%CI：2.3，3.6）。在半城市和农村诊所就诊的妇女以及有3-4次和5次妊娠史的妇女中，梅毒感染的风险显著较高（p < 0.05）。婚姻状况和教育水平与两种感染的任何一种都没有统计学意义。38，928人中有109人同时感染艾滋病毒和梅毒（0.3结论：艾滋病毒感染率（5.6%）和梅毒的总患病率在坦桑尼亚参加产前保健诊所的孕妇中发现的2.5%的婴儿死亡率要求进一步加强目前的干预措施，其中包括在生殖和儿童健康诊所中加强预防母婴传播服务的整合。
Background: The occurrence of HIV-1 and syphilis infections during pregnancy poses major health risks to the foetus due to mother-to-child transmission. We conducted surveillance of HIV and syphilis infections among pregnant women attending antenatal clinics (ANCs) in Mainland Tanzania in 2011.Methods: This surveillance was carried out in 133 ANCs selected from 21 regions in Tanzania. In each region, six ANC sites were selected, with urban, semi-urban, and rural areas contributing two each. All pregnant women who were attending selected sentinel ANC sites for the first time at any pregnancy between September and December 2011 were enrolled. Serial ELISA assays were performed to detect HIV infection in an unlinked anonymous manner using dried blood spot (DBS) after routine syphilis testing. Data analysis was conducted using Stata v.12 software.Results: A total of 39,698 pregnant women representing 2.4% of all pregnant women (1.68 million) attending ANCs in the Mainland Tanzania were enrolled. The overall HIV prevalence was found to be 5.6% (95 % CI: 5.4-5.8%). The risk for HIV infection was significantly higher among women aged 25-34 (cOR = 1.97, 95% CI: 1.79-2.16; p < 0.05), older than 35 years (cOR = 1.88, 95% CI: 1.62-2.17; p < 0.05) and those having 1-2 and 3-4 previous pregnancies. HIV infection was less prevalent among women attending rural ANC clinics (cOR = 0.46, 95 % CI 0.4-0.52; p < 0.05). The overall syphilis prevalence was 2.5% (95% CI: 2.3, 3.6). The risk for syphilis infection was significantly higher among women attending semi-urban and rural clinics and those having 3-4, and 5 previous pregnancies (p < 0.05). Marital status and level of education were not statistically significant with either of the two infections. HIV and syphilis co-infections occurred in 109 of 38,928 (0.3Conclusion: The overall prevalence of HIV infection (5.6%) and syphilis (2.5%) found among pregnant women attending ANC clinics in Tanzania calls for further strengthening of current intervention measures, which include scaling up the integration of prevention of mother to child transmission (PMTCT) services in Reproductive and Child Health (RCH) clinics.