Transcriptional regulation of TNF-alpha production in neutropenia.
Transcriptional regulation of TNF-alpha production in neutropenia.
复制标题
中性粒细胞减少症中 TNF-α 产生的转录调节。
DOI：
10.1152/ajpregu.00322.2004
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Albina,JorgeE
中科院分区：
文献类型：
--
作者：
Daley,JeanM;Ivanenko-Johnston,Tetiana;Reichner,JonathanS;Albina,JorgeE
Neutropenia has been shown to markedly increase plasma TNF-α concentration after LPS injection and to enhance LPS-induced mortality. Experiments reported here demonstrate that the 15-fold higher plasma TNF-α concentration elicited by LPS in neutropenic vs. nonneutropenic unanesthetized mice correlated with increased hepatic and splenic, but not pulmonary, TNF-α mRNA. Core 2 β-1,6-N-acetylglucosaminyltransferase-null and CD18-deficient mice also exhibited exaggerated plasma TNF-α responses to LPS injection. Findings suggest that extravasated neutrophils inhibit systemic TNF-α production and that they do so through organ-selective mechanisms involving CD18 integrin and selectin binding.
