Distinct intrinsic functional brain network abnormalities in methamphetamine-dependent patients with and without a history of psychosis
Distinct intrinsic functional brain network abnormalities in methamphetamine-dependent patients with and without a history of psychosis
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DOI：
10.1111/adb.12478
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发表时间：
2018-01-01
影响因子：
3.4
通讯作者：
Stein, Dan I.
中科院分区：
文献类型：
--
作者：
Ipser, Jonathan C.;Uhlmann, Anne;Stein, Dan I.
长期使用甲基苯丙胺与执行功能缺陷有关，这表明大脑中的认知控制网络（CCN）功能失调。同样，内在 CCN 和默认模式网络 (DMN) 之间的异常连接也与临床人群认知功能不佳有关。因此，我们测试了甲基苯丙胺的使用在多大程度上预测了这些网络之间的异常连接，以及这些异常是否如预测的那样在有甲基苯丙胺相关精神病（MAP）病史的患者中复合。静息态 fMRI 数据来自 46 名甲基苯丙胺依赖患者 [19 名有 MAP，27 名没有 (MD)] 以及 26 名健康对照 (CTRL)。进行多变量网络建模和全脑体素连接分析，以确定使用独立成分分析方法 (meta-ICA) 确定的四个认知控制网络和三个 DMN 网络之间内在连接的群体差异。还研究了网络连接性与精神病症状严重程度以及抗精神病药物治疗和甲基苯丙胺使用变量的关系。在 MAP 患者的右额顶叶和前部 DMN 网络之间观察到了超连接的有力证据，并且随着抗精神病药物治疗时间的增加而“正常化”。反相关的前DMN-背侧注意力网络活动的减弱也仅限于该组。随着戒除甲基苯丙胺持续时间的延长，在 MD 参与者中检测到的前 DMN 网络和后 DMN 网络之间的耦合增强变得不那么明显。总之，我们观察到慢性甲基苯丙胺暴露下 DMN 网络之间 RSN 连接的变化，以及 DMN-CCN 耦合异常，这与任务相关网络活动偏向中可能存在的 MAP 特异性额顶叶缺陷一致。
Chronic methamphetamine use is associated with executive functioning deficits that suggest dysfunctional cognitive control networks (CCNs) in the brain. Likewise, abnormal connectivity between intrinsic CCNs and default mode networks (DMNs) has also been associated with poor cognitive function in clinical populations. Accordingly, we tested the extent to which methamphetamine use predicts abnormal connectivity between these networks, and whether, as predicted, these abnormalities are compounded in patients with a history of methamphetamine-associated psychosis (MAP). Resting-state fMRI data were acquired from 46 methamphetamine-dependent patients [19 with MAP, 27 without (MD)], as well as 26 healthy controls (CTRL). Multivariate network modelling and whole-brain voxel-wise connectivity analyses were conducted to identify group differences in intrinsic connectivity across four cognitive control and three DMN networks identified using an independent components analysis approach (meta-ICA). The relationship of network connectivity and psychotic symptom severity, as well as antipsychotic treatment and methamphetamine use variables, was also investigated. Robust evidence of hyper-connectivity was observed between the right frontoparietal and anterior DMN networks in MAP patients, and 'normalized' with increased duration of treatment with antipsychotics. Attenuation of anticorrelated anterior DMN-dorsal attention network activity was also restricted to this group. Elevated coupling detected in MD participants between anterior and posterior DMN networks became less apparent with increasing duration of abstinence from methamphetamine. In summary, we observed both alterations of RSN connectivity between DMN networks with chronic methamphetamine exposure, as well as DMN-CCN coupling abnormalities consistent with possible MAP-specific frontoparietal deficits in the biasing of task-appropriate network activity.