MODULATION OF NATURAL-KILLER CELL-ACTIVITY IN PATIENTS WITH ATOPIC-DERMATITIS
MODULATION OF NATURAL-KILLER CELL-ACTIVITY IN PATIENTS WITH ATOPIC-DERMATITIS
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DOI：
10.1111/1523-1747.ep12259055
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发表时间：
1984-01-01
影响因子：
6.5
通讯作者：
THESTRUPPEDERSEN, K
中科院分区：
文献类型：
--
作者：
JENSEN, JR;SAND, TT;THESTRUPPEDERSEN, K
36例中重度特应性皮炎成人患者的外周血淋巴细胞对51 Cr标记的[人白血病] K 562细胞的自然杀伤（NK）细胞活性降低。NK细胞活性的降低与血清IgE水平无关，但与皮肤病的严重程度有关。将自体单核细胞加入到测定中降低了NK细胞活性并掩盖了γ-IFN-γ的增强作用。在4小时测定中加入干扰素。淋巴细胞的NK细胞活性可以通过加入前列腺素E1在体外降低，或者通过加入γ-干扰素类似于来自无特应性疾病的人的淋巴细胞。降低的NK细胞活性可能继发于皮肤病，并且是由于NK细胞和单核细胞之间的体内相互作用，或由于外周血中NK细胞数量少。
The peripheral blood lymphocytes of 36 adult patients with moderate to severe atopic dermatitis had reduced natural killer (NK) cell activity when measured against 51Cr-labeled [human leukemia] K 562 cells. The decrease in NK cells activity was not related to the serum IgE level, but was related to the severity of the skin disease. Addition of autologous monocytes to the assay reduced the NK cell activity and concealed the enhancing effect of .gamma.-interferon addition in a 4-h assay. The NK cell activity of lymphocytes could be reduced in vitro by addition of prostaglandin E1, or increased by addition of .gamma.-interferon similar to lymphocytes from persons without atopic disease. The reduced NK cell activity may be secondary to the skin disease, and due to in vivo interaction between NK cells and monocytes, or to low numbers of NK cells in peripheral blood.