The immunological synapse: A molecular machine controlling T cell activation
The immunological synapse: A molecular machine controlling T cell activation
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DOI：
10.1126/science.285.5425.221
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发表时间：
1999-07-09
期刊：
影响因子：
56.9
通讯作者：
Dustin, ML
中科院分区：
文献类型：
--
作者：
Grakoui, A;Bromley, SK;Dustin, ML
T淋巴细胞和抗原呈递细胞之间的特殊连接，免疫突触，由一圈粘附分子包围的T细胞受体的中心簇组成。免疫突触的形成现在被证明是一个活跃的、动态的机制，允许T细胞区分潜在的抗原配体，最初，T细胞受体配体参与新生突触的最外层环。这些复合物进入中心簇的运输依赖于T细胞受体-配体相互作用动力学。最后，在突触中心形成一个稳定的中心簇是T细胞增殖的决定性事件。
The specialized junction between a T lymphocyte and an antigen-presenting cell, the immunological synapse, consists of a central cluster of T cell receptors surrounded by a ring of adhesion molecules. Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic Ligands, initially, T cell receptor ligands were engaged in an outermost ring of the nascent synapse. Transport of these complexes into the central cluster was dependent on T cell receptor-ligand interaction kinetics. Finally, formation of a stable central cluster at the heart of the synapse was a determinative event for T cell proliferation.