Elevated Epstein-Barr Virus Seroreactivity Among Unaffected Members of Families With Nasopharyngeal Carcinoma
Elevated Epstein-Barr Virus Seroreactivity Among Unaffected Members of Families With Nasopharyngeal Carcinoma
复制标题
DOI：
10.1002/jmv.22121
复制
发表时间：
2011-10-01
影响因子：
12.7
通讯作者：
Shugart, Yin Yao
中科院分区：
文献类型：
--
作者：
Qin, Hai-De;Jia, Wei-Hua;Shugart, Yin Yao
爱泼斯坦巴尔病毒（EB病毒）抗原的血清抗体可用于预测鼻咽癌（NPC）的风险。为了研究来自多发性和散发性NPC家庭的健康家庭成员中EBV血清阳性率是否更高（即，与一般人群相比，对来自140个多重病例和413个散发病例家庭的2，665名未受影响的个人进行了一项研究。将EBV衣壳抗原伊加抗体（VCA-IgA）的滴度与来自普通人群的904名对照进行比较。VCA-IgA滴度在两个家系中的同胞间均具有高度显著性相关性（多重家系P < 0.0001，散发家系P = 0.0005），亲子对也有显著相关性（P < 0.0001和P = 0.0002）;配偶对相关，但在较低的显著性水平（P = 0.0790和P = 0.0040）。与对照组相比，在多重家庭的一级亲属中，兄弟姐妹、父母和子女的年龄和性别调整优势比（OR）分别为2.06（95%置信区间1.56-2.71）、3.55（2.24-5.64）和2.25（1.57-3.23）。在散发家系中，兄弟姐妹和父母的校正OR分别为1.55（1.21-2.00）和2.08（1.51-2.86）。配偶的调整后P值在多重家庭中失去了显著性，但在散发家庭中仍然具有显著性（P = 0.0146）。总之，在多发性和散发性鼻咽癌家族中，未受影响的家族成员中EBV血清阳性率升高。J. Med. Virol. 83：1792-1798，2011. (C)2011 Wiley-Liss，Inc.
Serum antibodies to Epstein Barr virus (EBV) antigens can be used to predict the risk of nasopharyngeal carcinoma (NPC). To investigate whether EBV seropositivity rates were higher among healthy family members from multiplex and sporadic families with NPC (i.e., families with multiple or single cases) compared to the general population, a study was conducted on 2,665 unaffected individuals from 140 multiplex and 413 sporadic families. The titers of the IgA antibody to the EBV capsid antigen (VCA-IgA) were compared to those of 904 controls from the general population. The VCA-IgA titer was correlated among sibling pairs to a high significance in both family types (P < 0.0001 and P = 0.0005 for the multiplex and the sporadic families, respectively); parent offspring pairs also showed significant correlation (P < 0.0001 and P = 0.0002, respectively); and spouse pairs were correlated, but at lower significance levels (P = 0.0790 and P = 0.0040, respectively). When compared to the controls, among first-degree relatives in the multiplex families, the age- and gender-adjusted odds ratio (OR) was 2.06 (95% confidence interval 1.56-2.71), 3.55 (2.24-5.64), and 2.25 (1.57-3.23) for siblings, parents, and children, respectively. In the sporadic families, the adjusted OR was 1.55 (1.21-2.00) and 2.08 (1.51-2.86) for siblings and parents, respectively. The adjusted P-value of spouses lost significance in the multiplex families, but remained significant in the sporadic families (P = 0.0146). In conclusion, EBV seropositivity rates were elevated among unaffected family members in both multiplex and sporadic families with NPC. J. Med. Virol. 83:1792-1798, 2011. (C) 2011 Wiley-Liss, Inc.