SYNCHRONIZED BURSTING OF CA1 HIPPOCAMPAL PYRAMIDAL CELLS IN THE ABSENCE OF SYNAPTIC TRANSMISSION
SYNCHRONIZED BURSTING OF CA1 HIPPOCAMPAL PYRAMIDAL CELLS IN THE ABSENCE OF SYNAPTIC TRANSMISSION
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DOI：
10.1038/300448a0
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发表时间：
1982-01-01
期刊：
影响因子：
64.8
通讯作者：
HAAS, HL
中科院分区：
文献类型：
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作者：
JEFFERYS, JGR;HAAS, HL
神经元放电的同步，在癫痫中最引人注目，通常归因于突触相互作用1 -5。我们现在已经发现了一种由非突触机制产生的节律性自发爆发活动。在低Ca 2+、高Mg 2+溶液中孵育阻断化学突触传递后，在大鼠海马脑片中发生，并几乎以时钟规律持续数小时。我们在这里报告，自发放电的所有神经元记录在切片增加，与已知的影响，钙离子对膜特性和突触transmission 6 -10一致，但同步的“场爆发”，并推测其潜在的机制，仅限于人口的锥体神经元在海马CA 1区。因此，这些低Ca 2+场爆发是不同的Ca 2+依赖的同步爆发引起的切片青霉素起源于人口的锥体细胞的CA 3区域1 -3。
The synchronization of neuronal firing, seen at its most dramatic in the epilepsies, has generally been attributed to synaptic interactions1–5. We have now discovered a rhythmic spontaneous bursting activity produced by non-synaptic mechanisms. It develops in rat hippocampal slices after chemical synaptic transmission has been blocked by incubation in low Ca2+, increased Mg2+solutions, and persists with almost clockwork regularity for several hours. We report here that spontaneous firing of all the neurones recorded in the slice increased, consistent with the known effects of Ca2+on membrane properties and synaptic transmission6–10, but the synchronous ‘field bursts’, and presumably their underlying mechanisms, were restricted to the population of pyramidal neurones in the hippocampal CA1 region. Thus, these low Ca2+field bursts are different from the Ca2+-dependent synchronous bursts induced in slices by penicillin which originate in the population of pyramidal cells of the CA3 region1–3.