The distribution of tyrosine hydroxylase in the canary brain: demonstration of a specific and sexually dimorphic catecholaminergic innervation of the telencephalic song control nuclei
The distribution of tyrosine hydroxylase in the canary brain: demonstration of a specific and sexually dimorphic catecholaminergic innervation of the telencephalic song control nuclei
复制标题
DOI：
10.1007/s004410100360
复制
发表时间：
2001-05-01
影响因子：
3.6
通讯作者：
Balthazart, J
中科院分区：
文献类型：
--
作者：
Appeltants, D;Ball, GF;Balthazart, J
唱歌和与歌曲相关的听觉信息的处理可能会受到斑胸草雀大脑中儿茶酚胺活性的实验操作的影响。我们通过免疫细胞化学在雄性和雌性金丝雀大脑中研究了酪氨酸羟化酶（TH）的分布，酪氨酸羟化酶（TH）是儿茶酚胺合成的限速步骤。 TH (TH-ir) 免疫反应纤维在嗅叶、古纹状体和外侧隔核中特别丰富。在尾内侧新纹状体中观察到高密度的 TH-ir 篮状结构，该区域涉及歌曲感知和识别。在大多数男性中，高密度的 TH-ir 纤维勾勒出端脑歌曲控制核，包括高位发声中枢、古纹状体粗壮核、筋膜间核、前新纹状体大细胞核的外侧和内侧部分以及嗅叶 X 区。与周围的端脑相比，这些细胞核中对 TH 具有免疫反应性的纤维密度更高，这支持了歌曲控制细胞核的形态进化伴随着神经化学专门化的观点。一般来说，雌性动物中没有发现这种鸣叫控制区域的特定神经支配。雄性金丝雀鸣叫系统中高密度 TH-ir 纤维的具体存在以及这种神经支配的性别差异提供了解剖学证据，支持多巴胺和/或去甲肾上腺素在鸣叫学习和产生的调节中发挥重要作用的说法。
Singing and the processing of auditory information related to song can be affected by experimental manipulations of catecholamine activity in the brain of zebra finches, We investigated, by immunocytochemistry in the brain of male and female canaries, the distribution of tyrosine hydroxylase (TH), the rate-limiting step in the synthesis of catecholamines. Fibers immunoreactive for TH (TH-ir) were particularly abundant in the lobus parolfactorius, the paleostriatum primitivum, and the nucleus septalis lateralis. A high density of TH-ir basketlike structures was observed in the caudomedial neostriatum, an area involved in song perception and recognition. In most males, a high density of TH-ir fibers outlined the telencephalic song control nuclei including the high vocal center, the nucleus robustus archistriatalis, the nucleus interfascialis, the lateral and medial parts of the magnocellular nucleus of the anterior neostriatum, and area X of the lobus parolfactorius. The higher density of fibers immunoreactive for TH in these nuclei, compared with the surrounding telencephalon, supports the notion that the morphological evolution of the song control nuclei was accompanied by a neurochemical specialization. This specific innervation of the song control regions was, in general, not found in females. The specific presence of high densities of TH-ir fibers in the song system of male canaries and the sex difference of this innervation provide anatomical evidence in support of the claim that dopamine and/or norepinephrine play important roles in the modulation of song learning and production.