Population genetic diversity in relation to microsatellite heterogeneity
Population genetic diversity in relation to microsatellite heterogeneity
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DOI：
10.1002/(sici)1098-1004(1998)11:2
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发表时间：
1998-01-01
期刊：
影响因子：
3.9
通讯作者：
Wiegand, P
中科院分区：
文献类型：
--
作者：
Brinkmann, B;Junge, A;Wiegand, P
使用6个微卫星系统（HumCD 4、HumF 13 B、HumFES/FPS、HumTH 01、HumVWA和D21 S11），即所谓的STR（短串联重复序列），调查了9个人群（德国人、土耳其人、马达加斯加人、Ovambos人、乌干达人、中国人、日本人、巴布亚人和澳大利亚原住民）。利用等位基因频率数据和测序结果比较不同群体间的遗传多样性。遗传差异取决于应用的STR。根据所研究的系统，我们将STR微变异分为三类：低微变异系统（LOMs）、中微变异系统（INMs）和高微变异系统（HIMs）。L0 M（STR：CD 4、FES、F13 B、TH 01）的特征在于5-15个之间的重复数目和稳定的重复序列。INM和希姆斯各自显示出重复序列的数量增加和重复基序中的额外序列变异。新突变的发生率与微变异的程度有关。系统发育树的重建导致聚类在早期分裂的非洲人口，然后进一步分支的亚洲/美拉尼西亚和高加索群体。(C)1998 Wiley-Liss，Inc.
Nine populations (Germans, Turks, Moroccans, Ovambos, Ugandans, Chinese, Japanese, Papuans, and Australian Aborigines) were investigated using six microsatellite systems (HumCD4, Hum F13B, HumFES/FPS, HumTH01, HumVWA, and D21S11), so called STRs (short tandem repeats). Allele frequency data and sequencing results were used to compare the population genetic diversity among these populations. The genetic differences varied depending on the STR applied. According to the systems investigated, we defined three categories of STR microvariation: LOMs (low microvariation systems), INMs (intermediate microvariation systems), and HIMs (high microvariation systems). LOMs (STRs: CD4, FES, F13B, TH01) are characterised by a number of repeats between 5-15 and a stable repeat sequence. INMs and HIMs each showed an increasing number of repeats and additional sequence variation in the repeat motifs. The rate of new mutations was associated with the extent of microvariation. The reconstruction of phylogenetic trees led to a clustering in an early split of the African populations followed by further branching of the Asian/Melanesian and the Caucasian groups. (C) 1998 Wiley-Liss, Inc.