Relationship between histologic type of primary lung cancer and carbon-11-L-methionine uptake with positron emission tomography.
Relationship between histologic type of primary lung cancer and carbon-11-L-methionine uptake with positron emission tomography.
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原发性肺癌组织学类型与正电子发射断层扫描碳-11-L-蛋氨酸摄取之间的关系。
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发表时间：
1989
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通讯作者：
Kengo Ito
中科院分区：
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作者：
T. Fujiwara;Taiju Matsuzawa;Kazuo Kubota;Y. Abe;Masatoshi Itoh;Hiroshi Fukuda;J. Hatazawa;S. Yoshioka;Keiichirou Yamaguchi;Kengo Ito
L-[甲基-11 C]-甲硫氨酸[（11 C]methionine）]已被证明是用于诊断人类癌症的有用氨基酸之一。我们研究了[11 C]蛋氨酸摄取与原发性肺癌组织学类型之间是否存在任何相关性。采用正电子发射断层扫描（PET）研究了16例患者，其中9例鳞状细胞癌，5例大细胞癌，1例小细胞癌和1例腺癌。所有患者的肺肿瘤中[11 C]甲硫氨酸都有高蓄积。我们通过半定量值DUR（微分摄取比）评估了[11 C]甲硫氨酸摄取到肿瘤中。大细胞癌（3.98 +/- 0.27）和鳞状细胞癌（2.92 +/- 0.30）之间[11 C]蛋氨酸摄取存在显著差异（p <0.01，Mann-Whitney检验）。结果提示，[11 C]蛋氨酸的积累与肺癌的组织学类型有关。这表明[11 C]蛋氨酸PET用于肺癌研究的新的潜在适用性。
L-[Methyl-11C]-methionine [( 11C]methionine) has proved to be one of the useful amino acids for the diagnosis of human cancer. We examined whether there was any correlation between [11C]methionine uptake and histologic type of primary lung cancer. Sixteen patients with nine squamous cell carcinoma, five large cell carcinoma, one small cell carcinoma, and one adenocarcinoma were studied using positron emission tomography (PET). All patients had high accumulation of [11C]methionine in lung tumors. We evaluated [11C]methionine uptake into the tumor by a semiquantitative value, DUR (Differential Uptake Ratio). There was significant difference (p less than 0.01, Mann-Whitney test) of [11C]methionine uptake between large cell carcinoma (3.98 +/- 0.27) and squamous cell carcinoma (2.92 +/- 0.30). The result suggested that there was correlation between [11C]methionine accumulation and the histologic type of lung cancer. This indicates a new potential applicability of [11C]methionine PET for the study of lung cancer.