Auditory resting-state functional connectivity in tinnitus and modulation with transcranial direct current stimulation
Auditory resting-state functional connectivity in tinnitus and modulation with transcranial direct current stimulation
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DOI：
10.3109/00016489.2015.1068952
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发表时间：
2015-07
影响因子：
1.4
通讯作者：
Shujiro B Minami;Naoki Oishi;Takahisa Watabe;K. Uno;K. Kaga;K. Ogawa
中科院分区：
文献类型：
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作者：
Shujiro B Minami;Naoki Oishi;Takahisa Watabe;K. Uno;K. Kaga;K. Ogawa
摘要结论：耳鸣患者左右听觉皮层的功能连接（FC）较弱。经颅直流电刺激（tDCS）的听觉皮层有可能作为一种工具，以调节神经元为基础的FC。目的：本研究调查了耳鸣患者应用tDCS的效果，并通过对刺激脑区的FC分析，在静息态功能磁共振成像（rs-fMRI）中寻找脑网络的调制。对象和方法：9例男性慢性耳鸣患者和10例听力正常的男性志愿者。受试者在tDCS之前和之后立即进行rs-fMRI评估。耳鸣患者在tDCS治疗前和治疗后1周填写自我评估问卷，以测量耳鸣状况。结果：耳鸣患者左右听皮层间的FC明显弱于对照组。tDCS治疗后，耳鸣组初级听觉皮层与躯体感觉区和运动区的连通性显著减少，但与听觉区和岛叶皮层的连通性显著增强（p < 0.005）。与此相反，在对照组中，初级听觉皮层与躯体感觉区、运动区、岛叶皮层和听觉区之间仍然存在很强的显著连通性。
Abstract Conclusions: The functional connectivity (FC) between the right and left auditory cortex is weak in tinnitus patients. Transcranial direct current stimulation (tDCS) over the auditory cortex has potential as a tool to modulate auditory-based FC. Objective: This study investigated the effects of applying tDCS in tinnitus patients, and searched for modulation of brain networks in resting-state functional magnetic resonance imaging (rs-fMRI) through an analysis of FC with the stimulated brain region. Subjects and methods: Nine male patients with chronic tinnitus and 10 male volunteers with normal hearing were enrolled. The subjects were evaluated with rs-fMRI immediately before and after tDCS. The tinnitus patients filled out the self-evaluation questionnaires designed to measure tinnitus conditions before tDCS treatment and 1 week afterwards. Results: The FC between the right and left auditory cortex was significantly weaker in tinnitus patients than in controls. After tDCS treatment, in the tinnitus group, the primary auditory cortex showed a reduction in the amount of statistically significant connectivity with the somatosensory area and motor area, but maintained strong significant connectivity (p < 0.005) with the auditory area and insular cortex. In contrast, in the control group, there remained strong significant connectivity between the primary auditory cortex and the somatosensory area, motor area, insular cortex, and auditory area.