A novel therapeutic effect of statins on nephrogenic diabetes insipidus.
A novel therapeutic effect of statins on nephrogenic diabetes insipidus.
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DOI：
10.1111/jcmm.12422
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发表时间：
2015-02
影响因子：
5.3
通讯作者：
Portincasa P
中科院分区：
文献类型：
--
作者：
Bonfrate L;Procino G;Wang DQ;Svelto M;Portincasa P
Statins competitively inhibit hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase, resulting in reduced plasma total and low-density lipoprotein cholesterol levels. Recently, it has been shown that statins exert additional ‘pleiotropic’ effects by increasing expression levels of the membrane water channels aquaporin 2 (AQP2). AQP2 is localized mainly in the kidney and plays a critical role in determining cellular water content. This additional effect is independent of cholesterol homoeostasis, and depends on depletion of mevalonate-derived intermediates of sterol synthetic pathways, i.e. farnesylpyrophosphate and geranylgeranylpyrophosphate. By up-regulating the expression levels of AQP2, statins increase water reabsorption by the kidney, thus opening up a new avenue in treating patients with nephrogenic diabetes insipidus (NDI), a hereditary disease that yet lacks high-powered and limited side effects therapy. Aspects related to water balance determined by AQP2 in the kidney, as well as standard and novel therapeutic strategies of NDI are discussed.
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DOI：
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发表时间：
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影响因子：
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