Combined analysis ofIKZF1deletions andCRLF2expression on prognostic impact in pediatric B-cell precursor acute lymphoblastic leukemia
Combined analysis ofIKZF1deletions andCRLF2expression on prognostic impact in pediatric B-cell precursor acute lymphoblastic leukemia
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IKZF1 缺失和 CRLF2 表达对儿童 B 细胞前体急性淋巴细胞白血病预后影响的联合分析
DOI：
10.1080/10428194.2020.1832668
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发表时间：
2020-10-13
影响因子：
2.6
通讯作者：
Zhang, Rui-Dong
中科院分区：
文献类型：
--
作者：
Cui, Lei;Gao, Chao;Zhang, Rui-Dong
为探讨IKZF 1缺失/CRLF 2高表达对儿童前体B细胞急性淋巴细胞白血病（BCP-ALL）预后的影响，对117例初诊BCP-ALL患儿的骨髓标本进行IKZF 1缺失和CRLF 2表达检测。发现16例（13.7%）患者存在IKZF 1缺失，这与较差的结局相关。CRLF 2高表达组的无事件生存率（EFS）明显低于CRLF 2低表达组。此外，IKZF 1（+）/CRLF 2（高）的联合建模将7.8%的病例确定为最高风险亚组（7年EFS 33.3 +/- 15.7%）。多因素分析显示，IKZF 1（+）/CRLF 2（高）仍是EFS的独立预后因素（HR：14.263，p = 0.019），IKZF 1缺失和CRLF 2高表达与预后差相关，IKZF 1（+）/CRLF 2（高）共存对高危BCP-ALL的综合预后模型有显著影响。
This study aimed to investigate the combined impact ofIKZF1deletions/high expression ofCRLF2on the prognosis of pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL).IKZF1deletions andCRLF2expression were assessed in bone marrow samples from 117 children with newly diagnosed BCP-ALL. Sixteen (13.7%) patients were found to harborIKZF1deletions, which was associated with inferior outcomes. The event-free survival (EFS) for patients with high -CRLF2expression was significantly worse than that for low -CRLF2expression. Moreover, combined modeling ofIKZF1(+)/CRLF2(high)identified 7.8% of cases as the highest risk subgroup (7-year EFS 33.3 +/- 15.7%). In a multivariate analysis,IKZF1(+)/CRLF2(high)remained a strong independent prognostic factor for EFS (HR: 14.263,p = 0.019).IKZF1deletions and high -CRLF2expression were associated with inferior outcomes, and the coexistence ofIKZF1(+)/CRLF2(high)had a significant impact on an integrated prognostic model for high-risk BCP-ALL.