The Blood-Spinal Cord Barrier: Morphology and Clinical Implications
The Blood-Spinal Cord Barrier: Morphology and Clinical Implications
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DOI：
10.1002/ana.22421
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发表时间：
2011-08-01
影响因子：
11.2
通讯作者：
Digicaylioglu, Murat
中科院分区：
文献类型：
--
作者：
Bartanusz, Viktor;Jezova, Daniela;Digicaylioglu, Murat
血-脊髓屏障（BSCB）是血脑屏障（BBB）的功能等同物，为脊髓的细胞成分提供专门的微环境。即使直觉上BSCB可以被认为是BBB进入脊髓的形态学延伸，证据表明事实并非如此。BSCB与BBB共享相同的主要构建块;然而，它们之间似乎存在形态和功能差异。BSCB的功能障碍在脊髓的几种病理状况的病因学或进展中起着重要作用，例如脊髓损伤、肌萎缩性侧索硬化症和辐射诱导的脊髓病。本文综述了BSCB的形态学、研究方法学以及BSCB功能障碍在脊髓疾病中的潜在作用，最后总结了BSCB的治疗方法。神经网络2011;70：194-206
The blood-spinal cord barrier (BSCB) is the functional equivalent of the blood-brain barrier (BBB) in the sense of providing a specialized microenvironment for the cellular constituents of the spinal cord. Even if intuitively the BSCB could be considered as the morphological extension of the BBB into the spinal cord, evidence suggests that this is not so. The BSCB shares the same principal building blocks with the BBB; nevertheless, it seems that morphological and functional differences may exist between them. Dysfunction of the BSCB plays a fundamental role in the etiology or progression of several pathological conditions of the spinal cord, such as spinal cord injury, amyotrophic lateral sclerosis, and radiation-induced myelopathy. This review summarizes current knowledge of the morphology of the BSCB, the methodology of studying the BSCB, and the potential role of BSCB dysfunction in selected disorders of the spinal cord, and finally summarizes therapeutic approaches to the BSCB. ANN NEUROL 2011;70:194-206