Lowest ever CD4 lymphocyte count (CD4 nadir) as a predictor of current cognitive and neurological status in human immunodeficiency virus type 1 infection - The Hawaii Aging with HIV Cohort
Lowest ever CD4 lymphocyte count (CD4 nadir) as a predictor of current cognitive and neurological status in human immunodeficiency virus type 1 infection - The Hawaii Aging with HIV Cohort
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DOI：
10.1080/13550280600915339
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发表时间：
2006-10-01
影响因子：
3.2
通讯作者：
Sacktor, Ned
中科院分区：
文献类型：
--
作者：
Valcour, Victor;Yee, Priscilla;Sacktor, Ned
低CD 4淋巴细胞计数是人类免疫缺陷病毒1型（HIV-1）神经系统疾病的标志物;但现在在接受高效抗逆转录病毒治疗的患者中不太常见。在这项研究中，作者确定了自我报告的CD 4最低点的可靠性及其对神经系统状态的预测价值。作者确定了高度的可靠性（r=.90）。调整年龄、当前CD 4计数和HIV-1持续时间后，CD 4最低值与当前诊断的HIV相关痴呆（HAD）（比值比[OR]：1.395（1.106-1.761），P=.005）和远端对称性多发性神经病（DSPN）（OR：1.479（1.221-1.769，P =.005））相关。
Low CD4 lymphocyte count was a marker for neurological disease in human immunodeficiency virus type 1 (HIV-1); but is now less common among patients with access to highly active antiretroviral therapy. In this study, the authors determine the reliability of self-reported CD4 nadir and its predictive value for neurological status. The authors identify a high degree of reliability (r=.90). After adjusting for age, current CD4 count, and duration of HIV-1, CD4 nadir relates to a current diagnosis of HIV-associated dimentia (HAD) (odds ratio [OR]: 1.395 (1.106-1.761), P=.005) and distal symmetric polyneuropathy (DSPN) (OR: 1.479 (1.221-1.769, P