The synergy of low lung function and low body mass index predicting all-cause mortality among older Japanese-American men.
The synergy of low lung function and low body mass index predicting all-cause mortality among older Japanese-American men.
复制标题
低肺功能和低体重指数的协同作用预测老年日裔美国男性的全因死亡率。
DOI：
10.1111/j.1532-5415.1997.tb03197.x
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发表时间：
1997
影响因子：
6.3
通讯作者：
Enright,PL
中科院分区：
文献类型：
--
作者：
Sharp,DS;Burchfiel,CM;Curb,JD;Rodriguez,BL;Enright,PL
目的：评估低标准化体重和肺功能受损在预测全因死亡率方面的联合特征。设计：一项基于人群的前瞻性队列研究。地点：夏威夷奥巴桑乔岛。参与者：檀香山心脏计划队列中存活的日裔美国男性，年龄71 - 93岁（N = 3059）.测量：体重指数（BMI-体重（kg）/身高平方（m））和1秒用力呼气量（FEV 1）以1991年至1993年队列检查中年龄和身高预测FEV 1的百分比表示。死亡率数据来源于队列死亡的持续跟踪。确定选定的危险因素与BMI（≤ 21，>21至<25，≥ 25 kg/m2）和FEV 1预测值百分比（≤ 70%，>70%）之间的关系。评估了这些协变量对联合BMI/百分比预测FEV 1水平与随后全因死亡率之间关系的影响。结果：最高年龄调整死亡率（91.9例死亡/1000人-年）在以FEV 1预测值≤ 70%和BMI ≤ 21 kg/m的关节状况为特征的男性中观察到。参照组的特征在于预测的FEV 1百分比> 70%和21 < BMI < 25 kg/m2。在对当前和过去吸烟行为的测量进行统计控制后，该比率降至3.2。在BMI的三个分层中，统计学相互作用反映在死亡率差异的异质性上（分别为49.7、21.8、− 9.6例死亡/人-年）和比率（分别为2.18，1.98，.66）比较男性FEV 1预测值百分比≤ 70%与> 70%。肺功能和相对体重的联合损失预测随后的全因死亡率超过每种疾病单独的累加或乘法效应。吸烟行为可能有助于这一观察。J Am Geriatr Soc 45：1464-1471，1997.
OBJECTIVE: To assess the joint characteristics of low standardized weight and compromised pulmonary function in predicting all‐cause mortality.DESIGN: A population‐based, prospective cohort study.SETTING: Oahu Island, Hawaii.PARTICIPANTS: Surviving Japanese‐American men of the Honolulu Heart Program cohort, 71 to 93 years of age (N = 3059).MEASUREMENTS: Body mass index (BMI ‐ weight in kilograms/square of height in meters) and 1‐second forced expiratory volume (FEV1) as a percentage of age‐and height‐predicted FEV1from the 1991 to 1993 examination of the cohort. Mortality data derived from the ongoing tracking of deaths of the cohort. Relations of selected risk factors among joint levels of BMI (≤ 21, >21 to <25, ≥ 25 kg/m2) and percent predicted FEV1(≤ 70%, >70%) were determined. The impact of these covariates on relations between joint BMI/percent predicted FEV1levels and subsequent all‐cause mortality was assessed.RESULTS: The highest age‐adjusted mortality rate (91.9 deaths per 1000 person‐years) was noted among men characterized by the joint conditions of percent predicted FEV1≤ 70% and BMI ≤ 21 kg/m.2This rate was 4.0 times the mortality rate of a “healthy” reference group characterized by percent predicted FEV1> 70% and 21 < BMI < 25 kg/m2. This rate ratio is attenuated to 3.2 upon statistical control for measures of current and past smoking behavior. Among the three strata of BMI, statistical interaction is reflected in a heterogeneity of mortality rate differences (49.7, 21.8, − 9.6 deaths/person‐year, respectively) and rate ratios (2.18, 1.98, .66, respectively) comparing men with percent predicted FEV1≤ 70% to > 70%.CONCLUSION: Joint loss of pulmonary function and relative weight is predictive of subsequent all‐cause mortality in excess of additive or multiplicative effects of each condition separately. Smoking behavior may contribute to this observation. J Am Geriatr Soc 45:1464–1471, 1997.