A PRESYNAPTIC EFFECT OF D-TUBOCURARINE IN NEUROMUSCULAR JUNCTION
A PRESYNAPTIC EFFECT OF D-TUBOCURARINE IN NEUROMUSCULAR JUNCTION
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DOI：
10.1111/j.1748-1716.1961.tb02208.x
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发表时间：
1961-01-01
期刊：
影响因子：
--
通讯作者：
NAESS, K
中科院分区：
文献类型：
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作者：
LILLEHEIL, G;NAESS, K
分离的膈神经隔膜制剂的终板电位（e.p.p.）已在发育至完成箭毒化期间和制剂恢复期间的不同阶段被记录。在大鼠膈神经隔膜制剂中，在增加箭毒化过程中获得的第一个效果的特征是 e 的恒定性。 p。 p。在强直刺激期间，即缺乏韦登斯基抑制。这种现象，随着e的迅速下降而发生。 p。 p.，在管箭毒碱的影响下发生，并且可能是由这种药理学影响引起的。结论是，韦登斯基抑制背后的机制必定是突触前起源的，并且可能是由于在运动神经最后的树状化中自然发生的阻止强直冲动传播的趋势的加强。讨论中更全面地讨论了以下主题： 1. 当使用单次刺激时，管箭毒碱可能的突触前作用与 Dale、Feldberg 和 Vogt (1936) 所证明的纯突触后作用的经典理论相关。 2. 强直刺激期间乙酰胆碱释放的可能过程。 3. 在重复脉冲的传输过程中，受体物质对乙酰胆碱可能会脱敏。 4.其他季铵化合物对神经纤维，尤其是无髓神经末梢的影响。
End-plate potentials (e. p. p.) of isolated phrenic nerve diaphragm preparation have been recorded at different stages during development to complete curarization and during recovery of the preparations. In rat phrenic nerve diaphragm preparations the first effect obtained during increasing curarization is characterized by the constancy of the e. p. p. during tetanic stimulation, i.e. by lack of Wedensky inhibition. This phenomenon, with a rapid decline of e. p. p., develops under the influence of tubocurarine and must probably be caused by this pharmacological influence. It is concluded that the mechanism behind the Wedensky inhibition must be of presynaptic origin, and probably be due to a reinforcement of the naturally occurring tendency to block of propagation of tetanic impulses in the last arborization of the motor nerve. The following topics are more comprehensively treated in the discussion: 1. The possible presynaptic effect of tubocurarine in relation to the classical theory of a pure postsynaptic one demonstrated by Dale, Feldberg and Vogt (1936) when single stimulations were used. 2. The possible course of release of acetylcholine during tetanic stimulation. 3. Possible desensitization of receptor substance to ACh during transmission of repetitive impulses. 4. Effect of other quaternary ammonium compounds on nerve fibres, especially on unmyelinated nerve endings.