Soluble intercellular adhesion molecule, vascular cell adhesion molecule, and impaired microvascular reactivity are early markers of vasculopathy in type 2 diabetic individuals without microalbuminuria
Soluble intercellular adhesion molecule, vascular cell adhesion molecule, and impaired microvascular reactivity are early markers of vasculopathy in type 2 diabetic individuals without microalbuminuria
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DOI：
10.2337/diacare.22.11.1865
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发表时间：
1999-11-01
期刊：
影响因子：
16.2
通讯作者：
Veves, A
中科院分区：
文献类型：
--
作者：
Lim, SC;Caballero, AE;Veves, A
目的：利用血管性假血友病因子(VWF)作为血管内皮功能的标志物，已有研究表明微量白蛋白尿的发生与2型糖尿病患者血管内皮细胞功能障碍的发生有关。研究设计和方法--我们使用激光多普勒成像扫描来测量前臂皮肤对1%乙酰胆碱(内皮依赖性)和1%硝普钠(内皮非依赖性)离子导入的反应。测定了20名健康受试者、45名正常白蛋白尿(尿白蛋白/肌酐)的血管内皮功能的多项指标--可溶性细胞间黏附分子(SVCAM)、可溶性血管细胞黏附分子(SVCAM)、vWF和微血管反应性
OBJECTIVE - Using von Willebrand Factor (VWF) as a marker of endothelial function, previous studies have shown that the development of microalbuminuria is associated with the onset of endothelial dysfunction in individuals with type 2 diabetes. We tested the hypothesis that endothelial dysfunction is already evident in normoalbuminuric individuals with type 2 diabetes.RESEARCH DESIGN AND METHODS - We used laser Doppler imaging scanning to measure vasodilation in the forearm skin in response to iontophoresis of 1% acetylcholine (endothelium-dependent) and 1% sodium nitroprusside (endothelium-independent). Multiple indicators of endothelial function-soluble intercellular adhesion molecule (sVCAM), soluble vascular cell adhesion molecule (sVCAM), vWF, and microvascular reactivity-were measured in 20 healthy control subjects, 45 normoalbuminuric (urinary albumin/creatinine ratio