COMPARATIVE ASPECTS OF LIPOGENESIS IN MAMMALIAN TISSUES
COMPARATIVE ASPECTS OF LIPOGENESIS IN MAMMALIAN TISSUES
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DOI：
10.1016/0026-0495(71)90059-x
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发表时间：
1971-01-01
影响因子：
9.8
通讯作者：
GORDON, ES
中科院分区：
文献类型：
--
作者：
SHRAGO, E;GLENNON, JA;GORDON, ES
与大鼠不同，人类脂肪组织从头合成脂肪酸的能力很差。柠檬酸裂解酶基本上不存在于人类脂肪组织中，并且其他相关的脂肪生成酶活性比大鼠附睾脂肪中低得多并且适应性差。对猴子肝脏进行的研究表明，至少间接地，灵长类动物和大鼠肝脏的关系更密切。通过比较多种动物的脂肪生成情况，提示大鼠可能是研究脂肪生成的碳途径和调控的较差的实验模型。
Human adipose tissue, unlike that of the rat, has a poor capacity to synthesize fatty acids de novo. The citrate cleavage enzyme is essentially absent from human adipose tissue, and other related lipogenic enzymatic activities are considerably lower and less adaptive than in rat epididymal fat. Studies carried out with monkey liver indicate, indirectly at least, a closer relationship of primate and rat liver. Comparison of lipogenesis in a number of animals indicates that the rat may be a poor experimental model to study the carbon pathway and regulation of lipogenesis.