PARP-1 via regulation of p53 and p16, is involved in the hydroquinone-induced malignant transformation of TK6 cells by decelerating the cell cycle.
PARP-1 via regulation of p53 and p16, is involved in the hydroquinone-induced malignant transformation of TK6 cells by decelerating the cell cycle.
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PARP-1 通过调节 p53 和 p16，通过减慢细胞周期参与氢醌诱导的 TK6 细胞恶性转化。
DOI：
10.1016/j.tiv.2021.105153
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发表时间：
2021-03
影响因子：
3.2
通讯作者：
Hao Luo
中科院分区：
文献类型：
--
作者：
Lu Zhai;Hairong Liang;Jinlin Du;Mingwei Sun;Weifeng Qiu;Huanwen Tang;Hao Luo
聚腺苷二磷酸核糖聚合酶-1（PARP-1）在DNA损伤修复中起着重要作用，同时也是一种肿瘤促进基因和抑癌基因。然而，PARP-1在氢醌诱导的TK 6细胞恶性转化中的作用仍有待进一步阐明。本研究旨在探讨PARP-1在氢醌诱导TK 6细胞恶性转化中的作用机制。结果表明，高浓度的PARP-1抑制HQ慢性染毒后TK 6细胞的恶性转化。我们进一步证实，PARP-1过表达阻断细胞增殖，并在体外和体内减慢细胞周期进程。免疫印迹分析表明PARP-1通过p16/Rb和p53调控细胞周期进程。因此，我们得出结论，PARP-1参与HQ诱导的恶性转化与增加p16/Rb和p53，从而导致细胞周期进程减慢。
Poly(ADP-ribose)polymerase-1 (PARP-1) plays a crucial role in DNA damage repair and could be viewed as both a tumor promoter and tumor-suppressor gene. However, the effects of PARP-1 in hydroquinone-induced malignant transformation of TK6 cells remain to be further elucidated. The present research evaluated the potential mechanism of PARP-1 in hydroquinone-induced malignant transformation of TK6 cells. The results indicated that high PARP-1 inhibited TK6 cells malignant transformation after chronic exposure to HQ. We further confirmed that PARP-1 overexpression blocked cell proliferation, and decelerated cell cycle progression in vitro and in vivo. The immunoblotting analysis indicated that PARP-1 regulated cell cycle progression via p16/Rb and p53. Therefore, we conclude that PARP-1 is involved in HQ-induced malignant transformation associated with increasing p16/Rb and p53 which resulting in decelerating the cell cycle progression.
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影响因子：
28.2
作者：
Schiewer MJ;Goodwin JF;Han S;Brenner JC;Augello MA;Dean JL;Liu F;Planck JL;Ravindranathan P;Chinnaiyan AM;McCue P;Gomella LG;Raj GV;Dicker AP;Brody JR;Pascal JM;Centenera MM;Butler LM;Tilley WD;Feng FY;Knudsen KE
通讯作者：
Knudsen KE
DOI：
10.22034/apjcp.2017.18.10.2845
发表时间：
2017-10-26
期刊：
Asian Pacific journal of cancer prevention : APJCP
影响因子：
--
作者：
Monger A;Boonmuen N;Suksen K;Saeeng R;Kasemsuk T;Piyachaturawat P;Saengsawang W;Chairoungdua A
通讯作者：
Chairoungdua A
影响因子：
11.2
作者：
C. Simbulan-Rosenthal;D. Rosenthal;Ruibai Luo;M. Smulson
通讯作者：
C. Simbulan-Rosenthal;D. Rosenthal;Ruibai Luo;M. Smulson
影响因子：
11.4
作者：
Vaziri, H;West, MD;Benchimol, S
通讯作者：
Benchimol, S
影响因子：
3.7
作者：
Dziaman T;Ludwiczak H;Ciesla JM;Banaszkiewicz Z;Winczura A;Chmielarczyk M;Wisniewska E;Marszalek A;Tudek B;Olinski R
通讯作者：
Olinski R