Regulation of Adaptive Immunity in Health and Disease by Cholesterol Metabolism.
Regulation of Adaptive Immunity in Health and Disease by Cholesterol Metabolism.
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DOI：
10.1007/s11882-015-0548-7
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发表时间：
2015-08
影响因子：
5.5
通讯作者：
Fessler MB
中科院分区：
文献类型：
--
作者：
Fessler MB
四十年前，人们观察到T细胞的刺激诱导细胞胆固醇的快速变化，这是增殖开始之前所必需的。回到这一现象的研究人员终于揭示了其分子基础。胆固醇运输及其失调现在也被认为强烈影响树突状细胞功能，T细胞极化和抗体反应。在这篇综述中，状态的文献综述胆固醇及其运输调节细胞的适应性免疫反应和体内疾病表型失调的适应性免疫，包括过敏，哮喘和自身免疫性疾病。新出现的证据支持他汀类药物和其他脂质靶向治疗在治疗这些疾病的潜在作用。正如血管生物学家在动脉粥样硬化的发病机制和治疗中接受免疫一样，过敏，肺病和其他学科的基础和临床免疫学家也应该寻求对脂质科学的基本理解。
Four decades ago, it was observed that stimulation of T cells induces rapid changes in cellular cholesterol that are required before proliferation can commence. Investigators returning to this phenomenon have finally revealed its molecular underpinnings. Cholesterol trafficking and its dysregulation are now also recognized to strongly influence dendritic cell function, T cell polarization, and antibody responses. In this review, the state of the literature is reviewed on how cholesterol and its trafficking regulate the cells of the adaptive immune response and in vivo disease phenotypes of dysregulated adaptive immunity, including allergy, asthma, and autoimmune disease. Emerging evidence supporting a potential role for statins and other lipid-targeted therapies in the treatment of these diseases is presented. Just as vascular biologists have embraced immunity in the pathogenesis and treatment of atherosclerosis, so should basic and clinical immunologists in allergy, pulmonology, and other disciplines seek to encompass a basic understanding of lipid science.