Cilia and cilia-associated proteins in cancer.
Cilia and cilia-associated proteins in cancer.
复制标题
DOI：
10.1016/j.ddmec.2013.03.004
复制
发表时间：
2013-12-01
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
初级纤毛在许多发育和慢性疾病的发病机制中是一个公认的目标，最近作为一种与癌症相关的结构引起了人们的兴趣。在这里，我们讨论纤毛的变化可以促进肿瘤的形成和生长的机制。我们强调了纤毛依赖性信号通路和蛋白的癌症相关性，包括mTOR、VHL、TSC、WNT、Aurora-A、NEDD9和Hedgehog，并强调了纤毛功能障碍在肾细胞癌、髓母细胞瘤和乳腺癌中的新作用。
The primary cilium is a well-established target in the pathogenesis of numerous developmental and chronic disorders, and more recently is attracting interest as a structure relevant to cancer. Here we discuss mechanisms by which changes in cilia can contribute to the formation and growth of tumors. We emphasize the cancer-relevance of cilia-dependent signaling pathways and proteins including mTOR, VHL, TSC, WNT, Aurora-A, NEDD9, and Hedgehog, and highlight the emerging role of ciliary dysfunction in renal cell carcinoma, medulloblastoma, and breast cancer.