Synthesis of glycosaminoglycan oligosaccharides. Part 5: Synthesis of a putative heparan sulfate tetrasaccharide antigen involved in prion diseases
Synthesis of glycosaminoglycan oligosaccharides. Part 5: Synthesis of a putative heparan sulfate tetrasaccharide antigen involved in prion diseases
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DOI：
10.1016/j.tet.2010.08.004
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发表时间：
2010-10-02
期刊：
影响因子：
2.1
通讯作者：
Fuegedi, Peter
中科院分区：
文献类型：
--
作者：
Daragics, Katalin;Fuegedi, Peter
The synthesis of the putative prion-associated heparan sulfate tetrasaccharide containing two D-glucuronic acid units is reported. Key to the synthesis were the differentiation of the N-acetylated and N-unsubstituted glucosamine units, the high-yielding glucosylation at O-4 of an N-acetyl-o-glucosamine derivative and the alpha-selective glycosylation of the 4'-OH group of a beta-D-GlcpA-(1 -> 4)-D-GlcpNAc disaccharide building block with a disaccharide thioglycoside donor. (C) 2010 Elsevier Ltd. All rights reserved.
