Hypercholesterolemia and Lifetime Risk of Coronary Heart Disease in the General Japanese Population: Results from the Suita Cohort Study
Hypercholesterolemia and Lifetime Risk of Coronary Heart Disease in the General Japanese Population: Results from the Suita Cohort Study
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DOI：
10.5551/jat.49098
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发表时间：
2020-01-01
影响因子：
4.4
通讯作者：
Miyamoto, Yoshihiro
中科院分区：
文献类型：
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作者：
Sugiyama, Daisuke;Turin, Tanvir Chowdhury;Miyamoto, Yoshihiro
目的：终身风险（LTR）是衡量疾病负担的指标，它表示一组人在给定指数年龄的剩余寿命中发生特定疾病的概率。这一措施有助于在人口水平上呈现疾病的风险动态，这构成了预防的重要公共卫生信息。到目前为止，还没有研究调查冠心病（CHD）的LTR与亚洲人群高胆固醇血症的关系。因此，我们根据血清低密度脂蛋白胆固醇（LDL-C）估计CHD的LTR。方法：本研究的参与者包括2，559名男性和2，848名女性，参加了1989年至2007年随访的城市居民的Suita队列研究，共69，823人年。我们估计了有或无高胆固醇血症的参与者中首次CHD事件的性别和指数年龄特异性LTR结果：男性高胆固醇血症患者的LTR为47.2%（10/10），而男性高胆固醇血症患者的LTR为47.2%（10/10），而男性高胆固醇血症患者的LTR为47.2%（10/10）。（95%置信区间[CI]：29.3-65.1%）和44.5%（95% CI：21.4-68.5%）。患有高胆固醇血症的女性的LTR也高于没有高胆固醇血症的女性。然而，与男性相比，他们的LTR在所有指数年龄段都较低。这些结果并没有不同的高胆固醇血症定义的非高密度脂蛋白cholesterolesterol.Conclusions：高胆固醇血症的存在增加了LTR冠心病在日本人口，特别是在男性。这一估计可用于在人口一级的预防性知识转化工作。
Aim: Lifetime risk (LTR) is a measure of disease burden, which presents the probability of occurrence of a specific disease in the remaining lifetime of a group of people for a given index age. This measure is useful for presenting the risk dynamics of a disease at the population level, which constitutes important public health information toward prevention. To date, there have been no studies investigating the LTR for coronary heart diseases (CHDs) in relation to hypercholesterolemia in Asian populations. Therefore, we estimated the LTR of CHDs according to serum low-density lipoprotein cholesterol (LDL-C).Methods: The participants included in this study were 2,559 men and 2,848 women, enrolled in the Suita Cohort Study of urban residents followed up from 1989 to 2007 for a total of 69,823 person-years. We estimated the sex- and index-age-specific LTR for the first CHD event among participants with or without hypercholesterolemia (LDL-C >= 160 mg/dL), accounting for the competing risk for mortality.Results: For men with hypercholesterolemia, the LTR was 47.2% (95% confidence interval [CI]: 29.3-65.1%) and 44.5% (95% CI: 21.4-68.5%) for those aged 45 and 75, respectively. The LTRs of women with hypercholesterolemia were also higher than of those without hypercholesterolemia. However, their LTRs were lower for all index ages compared to men. These results did not differ for hypercholesterolemia defined by non-high-density lipoprotein cholesterol.Conclusions: The presence of hypercholesterolemia increases the LTR for CHDs in the Japanese population, especially in men. This estimate can be used in preventive knowledge translation efforts at the population level.