Dissociable neural correlates for familiarity and recollection during the encoding and retrieval of pictures
Dissociable neural correlates for familiarity and recollection during the encoding and retrieval of pictures
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DOI：
10.1016/j.cogbrainres.2003.10.010
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发表时间：
2004-02-01
期刊：
影响因子：
--
通讯作者：
Knight, RT
中科院分区：
文献类型：
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作者：
Duarte, A;Ranganath, C;Knight, RT
来自行为研究的结果支持了这样的观点，即识别记忆至少可以由两个不同的过程支持，即回忆和熟悉。然而，目前还不清楚这两种形式的记忆是否反映了神经上不同的过程。此外，还不清楚回忆和熟悉是否可以被认为主要在提取加工方面不同，或者它们是否另外在编码方面不同。为了解决这些问题，我们使用事件相关脑电位(ERPs)来监测编码和提取时熟悉和回忆的神经关联。受试者在两种类型的学习块中学习物体的图片，然后在提取过程中进行记忆-知道判断和来源记忆判断。结果表明，在编码过程中，后续熟悉性和回忆的神经关联是平行启动的，但在头皮地形和时间进程上表现出差异。随后的基于熟悉度的再认与左侧增强的阳性反应有关，在300-450ms的头皮前部位观察到，而随后的回忆与在300-450ms的头皮前部位的地形图上明显的右侧阳性反应和450-600ms的双侧活动相关。在提取过程中，与熟悉程度相关的神经关联比与回忆相关的神经关联出现得更早。熟悉与额极头皮部位150-450ms的阳性增强有关，而回忆与双侧额叶(300-600ms)和顶叶(450-800ms)的ER-P阳性调节有关。这些结果表明，熟悉性和回忆反映了编码和提取时不同的神经记忆过程的结果。(C)2003爱思唯尔B.V.保留所有权利。
Results from behavioral studies have supported the idea that recognition memory can be supported by at least two different processes, recollection and familiarity. However, it remains unclear whether these two forms of memory reflect neurally distinct processes. Furthermore, it is unclear whether recollection and familiarity can be best conceived as differing primarily in terms of retrieval processing, or whether they additionally differ at encoding. To address these issues, we used event-related brain potentials (ERPs) to monitor neural correlates of familiarity and recollection at both encoding and retrieval. Participants studied pictures of objects in two types of study blocks and subsequently made remember-know and source memory judgments during retrieval. Results showed that, during encoding, neural correlates of subsequent familiarity and recollection onsetted in parallel, but exhibited differences in scalp topography and time course. Subsequent familiarity-based recognition was associated with a left-lateralized enhanced positivity and observed at anterior scalp sites from 300 to 450 ms, whereas subsequent recollection was associated with a topographically distinct right-lateralized positivity at anterior scalp sites from 300 to 450 ms and bilateral activity from 450 to 600 ms. During retrieval, neural correlates of familiarity emerged earlier than correlates of recollection. Familiarity was associated with an enhanced positivity at frontopolar scalp sites from 150 to 450 ms, whereas recollection was associated with positive ER-P modulations over bilateral frontal (300-600 ms) and parietal (450-800 ms) sites. These results demonstrate that familiarity and recollection reflect the outcome of neurally distinct memory processes at both encoding and retrieval. (C) 2003 Elsevier B.V. All rights reserved.