Expression of cytokeratins 7 and 20 in primary carcinomas of the stomach and colorectum and their value in the differential diagnosis of metastatic carcinomas to the ovary
Expression of cytokeratins 7 and 20 in primary carcinomas of the stomach and colorectum and their value in the differential diagnosis of metastatic carcinomas to the ovary
复制标题
DOI：
10.1053/hupa.2002.129422
复制
发表时间：
2002-11-01
期刊：
影响因子：
3.3
通讯作者：
Kim, WH
中科院分区：
文献类型：
--
作者：
Park, SY;Kim, HS;Kim, WH
细胞角蛋白（CK） 7和20在各种原发和转移性癌中的表达已被研究，它们的测定可能有助于区分转移性癌的起源部位。然而，对于决定其在原发性胃癌和结直肠癌中表达模式变化的因素知之甚少。我们利用组织芯片技术研究了CK7和CK20在289例胃癌和225例结直肠癌中的表达。为了评价CK7和CK20在胃癌或结直肠癌卵巢转移中的表达规律，我们对54例卵巢转移癌进行了检测。结果发现，71%（289例中有207例）的胃癌CK7阳性，而只有9%（225例中有21例）的结直肠癌CK7阳性，41%（289例中有117例）的胃癌和73%（225例中有165例）的结直肠癌CK20阳性。CK7+/CK20-的比例在胃癌中最高，为46%（289例中的132例），并且与Lauren的组织学分类无关（肠型占46%，弥漫性占45%）。CK7和CK20在结直肠癌中的表达模式因肿瘤的组织学分级和部位不同而不同。CK7-/CK20+在结直肠癌中所占比例最大（68%），这取决于肿瘤的组织学分级（75%为低级别，52%为高级别）和位置（46%为右侧，76%为左侧）。此外，42%（18 / 43）转移至卵巢的胃癌为CK7+/CK20-，而19%（8 / 43）为CK7-/CK20+。所有的结直肠。卵巢转移癌除1例为CK7-/CK20-外均为CK7-/CK20+。综上所述，CK7和CK20在原发性胃癌中的表达模式差异较大，在结直肠癌中的表达模式与组织学分级和肿瘤部位有关。CK7-/CK20+表达模式在卵巢转移性结直肠癌中是特异性的，但在转移性卵巢癌中结直肠起源的可预测性较低。《哀歌》33:107 -1085。版权所有，爱思唯尔科学（美国）。版权所有。
The expressions of cytokeratin (CK) 7 and 20 have been studied in various primary and metastatic carcinomas, and their determination may help distinguish the site of origin of metastatic carcinomas. However, little is known about the factors that determine variations in their expression patterns in primary gastric and colorectal carcinomas. We investigated the expressions of CK7 and CK20 in 289 cases of gastric carcinoma and 225 cases of colorectal carcinoma using a tissue microarray. To evaluate CK7 and CK20 expression patterns of ovarian metastases from gastric or colorectal carcinomas, 54 cases of metastatic carcinomas to the ovary were examined. It was found that 71% (207 of 289) of the gastric carcinomas stained positively for CK7, whereas only 9% (21 of 225) of the colorectal carcinomas proved to be CK7 positive, and that 41% (117 of 289) of the gastric carcinomas and 73% (165 of 225) of the colorectal carcinomas were CK20 positive. The proportion of CK7+/CK20- was highest in the gastric carcinomas at 46% (132 of 289), and was independent of the histologic classification of Lauren (46% of the intestinal type, 45% of the diffuse type). The CK7 and CK20 expression patterns were different in colorectal carcinomas according to histologic grade and location of the tumor. CK7-/CK20+ had the greatest proportion (68%) in colorectal carcinomas, and this was dependent on the tumor's histologic grade (75% of low-grade versus 52% of high-grade) and location (46% of right-sided versus 76% of left-sided). Moreover, 42% (18 of 43) of gastric carcinomas metastatic to the ovary were CK7+/CK20-, whereas 19% (8 of 43) were CK7-/CK20+. All colorectal. cancers metastatic to the ovary were CK7-/CK20+, except 1 case that was CK7-/CK20-. In conclusion, the CK7 and CK20 expression patterns in primary gastric carcinomas vary considerably, and those in colorectal carcinomas are associated with histologic grade and tumor location. The CK7-/CK20+ expression pattern is specific for metastatic colorectal carcinomas to the ovary, but has low predictability for colorectal origin in metastatic ovarian carcinoma. HUM PATHOL 33:1078-1085. Copyright 2002, Elsevier Science (USA). All rights reserved.