In vivo cardiovasculogenesis by direct injection of isolated adult mesenchymal stem cells
In vivo cardiovasculogenesis by direct injection of isolated adult mesenchymal stem cells
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DOI：
10.1016/s0014-4827(03)00132-0
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发表时间：
2003-08-01
影响因子：
3.7
通讯作者：
Umezawa, A
中科院分区：
文献类型：
--
作者：
Gojo, S;Gojo, N;Umezawa, A
间充质干细胞(MSCs)的特性具有重要的生物学和临床意义。我们证明，CD34(低)、c-kit(+)、CD140a(+)、Sca-1(高)所定义的分离的MSCs能够通过直接注射到成人心脏中分化为心肌细胞、内皮细胞、周细胞或平滑肌细胞。在骨骼肌和肺中，它们也有助于血管系统的形成。MSCs未转化为恶性细胞，也未形成过多的细胞外基质。本研究提示，MSCs可能为心肺疾病患者提供理想的心血管细胞供体来源。(C)2003年埃尔塞维尔科学公司(美国)。版权所有。
The characterization of mesenchymal stem cells (MSCs) is of biological and clinical interest. We demonstrate that isolated MSCs, defined by CD34(low) c-kit(+) CD140a(+) Sca-1(high), are able to differentiate into cardiomyocytes, endothelial cells, and pericytes or smooth muscle cells by direct injection into adult heart. In skeletal muscle and lung, they also contributed to formation of the vasculature. MSCs did not transform into malignant cells or form excess extracellular matrix. This study suggests that MSCs may supply an ideal donor source of cardiovascular cells in patients with cardiopulmonary diseases. (C) 2003 Elsevier Science (USA). All rights reserved.