Effects of NMDA antagonists on seizure thresholds induced by intrahippocampal microdialysis of picrotoxin in freely moving rats
Effects of NMDA antagonists on seizure thresholds induced by intrahippocampal microdialysis of picrotoxin in freely moving rats
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DOI：
10.1016/0304-3940(96)13084-6
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发表时间：
1996-10-25
影响因子：
2.5
通讯作者：
SierraMarcuno, G
中科院分区：
文献类型：
--
作者：
SierraParedes, G;SierraMarcuno, G
通过观察N-甲基-D-天冬氨酸（NMDA）受体拮抗剂2-氨基-5-磷酸戊酸（AP-5）和地佐环平（MK-801）对癫痫发作阈的影响，分析了NMDA受体在印防己毒素微灌流所致癫痫发作阈个体差异中的作用。Rme发现了由AP-5诱导的增加的阈值水平与每个个体动物的对照癫痫发作水平之间的相关性。然而，未发现与MK-801诱导的阈值水平升高相关。这些数据表明，在不同的动物癫痫发作阈值的个体差异反映了NMDA介导的活动的动态过程，并强调整体动物模型的价值，以分析NMDA受体的功能。
The role of N-methyl-D-aspartate (NMDA) receptors on individual variations in animal seizure threshold induced by picrotoxin microperfusion in the hippocampus of freely moving rats was analyzed by testing the effects of NMDA receptor antagonists 2-amino 5-phosphonovalerate (AP-5) and dizocilpine (MK-801) on individual seizure thresholds. rme found a correlation between the increased threshold levels induced by AP-5 and control seizure levels of each individual animal. However, no correlation was found with the increased threshold level induced by MK-801. These data suggest that the individual variations in seizure threshold in different animals reflect dynamic processes of NMDA mediated activity and emphasizes the value of whole-animal models to analyze NMDA receptor functions.